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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 113 - 119 (7page)
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초록· 키워드
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Porphyromonas (P.) gingivalis lipopolysaccharide (Pg LPS)is the major pathogenic component of periodontal disease.
In this study, we have attempted to determine the expression profiles of the signal transduction pathway genes induced by Pg LPS in comparison with Escherichia (E.) coli LPS (Ec LPS). DC2.4 cells were treated for two hours with 1 μg/ml of Pg LPS or 0.5 μg/ml of Ec LPS. The total RNA from these cells was then isolated and reverse-transcribed. Gene expression profiles were then analyzed with a signal transduction pathway finder GEArray Q series kit and significant changes in expression were confirmed by real-time PCR. The microarray results indicated that several genes, including Tnfrsf10b, Vcam1, Scyb9, Trim25, Klk6, and Stra6 were upregulated in the DC2.4 cells in response to Pg LPS treatment,but were downregulated or unaffected by Ec LPS. Realtime PCR revealed that the expression of Trim25, Scyb9 and Tnfrsf10b was increased over the untreated control. Notably,Trim25 and Tnfrsf10b were more strongly induced by Pg LPS than by Ec LPS. These results provide greater insight into the signal transduction pathways that are altered by P.
gingivalis LPS.
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참고문헌 (24)
참고문헌 신청
Amichay D / 1996 / Genes for chemokines MuMig and Crg-2 are induced in protozoan and viral infections in response to IFN-gamma with patterns of tissue expression that suggest
Asensio VC / 1997 / Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis / J Virol 10 : 7832 ~ 7840
Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
Barksby HE / 2009 / Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide / Clin Exp
Cutler CW / 1999 / Evidence and a novel hypothesis for the role of dendritic cells and Porphyromonas gingivalis in adult periodontitis / J Periodont Res 34 : 406 ~ 412
Asensio VC / 1997 / Chemokine gene expression in the brains of mice with lymphocytic choriomeningitis / J Virol 10 : 7832 ~ 7840
Banchereau J / 1998 / Dendritic cells and the control of immunity / Nature 392 : 245 ~ 252
Barksby HE / 2009 / Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide / Clin Exp
Cutler CW / 1999 / Evidence and a novel hypothesis for the role of dendritic cells and Porphyromonas gingivalis in adult periodontitis / J Periodont Res 34 : 406 ~ 412
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