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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 121 - 128 (8page)
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Porphyromonas gingivalis lipopolysaccharide (Pg LPS) is an important virulence factor in chronic periodontitis. The aim of this study was to compare the expression of inflammatory cytokine genes in Escherichia coli LPS (Ec LPS) and Pg LPS-stimulated mouse macrophage RAW 264.7 cells. Cells were treated with Ec LPS and Pg LPS for 18 hours, and the cytokine gene expression profile was assessed using microarrays and confirmed by real-time PCR. Microarray analysis showed that both types of LPS induced a significant increase in the expression of IL-17β,IL-2, Ccl4, Cxcl2 and TNFα compared with the control.
However, LT-b was up-regulated by Pg LPS but not by Ec LPS. Real-time PCR analysis of these genes showed similar results for LT-b, Ccl4, Cxcl2, and TNF-α but found that IL-17β and IL-2 were upregulated by Pg LPS but not by Ec LPS. These data indicate that Pg LPS stimulates the transcription of IL-17β, IL-2, Ccl4, Cxcl2, LT-b, and TNFα,all of which may be involved in the pathogenesis of chronic periodontitis.
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참고문헌 (25)
참고문헌 신청
Birkedal-Hansen H / 1998 / Chracterization of collagenolytic activity from strains of Bacteroides gingivalis / J Periodontal Res 23 : 258 ~ 264
Charo IF / 2006 / The many roles of chemokines and chemokine receptors in inflammation / N Engl J Med 354 : 610 ~ 621
Dzink JL / 1988 / The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease / J Clin Periodontol 15 : 316 ~ 323
Feng Z / 2006 / Role of bacteria in health and disease of periodontal tissues / Periodontol 2000 40 : 50 ~ 76
Gamonal J / 2001 / Characterization of cellular infiltrate, detection of chemokine receptor CCR5 and interleukin-8 and RANTES chemokines in adult periodontitis / J Periodonta
Charo IF / 2006 / The many roles of chemokines and chemokine receptors in inflammation / N Engl J Med 354 : 610 ~ 621
Dzink JL / 1988 / The predominant cultivable microbiota of active and inactive lesions of destructive periodontal disease / J Clin Periodontol 15 : 316 ~ 323
Feng Z / 2006 / Role of bacteria in health and disease of periodontal tissues / Periodontol 2000 40 : 50 ~ 76
Gamonal J / 2001 / Characterization of cellular infiltrate, detection of chemokine receptor CCR5 and interleukin-8 and RANTES chemokines in adult periodontitis / J Periodonta
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