지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
BAL은 일반적으로 기타 급성 백혈병보다 예후가 나쁘다고 알려져 있으나, 그 치료방침이 아직 확립되어 있지 않다. AML1-ETO 유전자 재배열은 BAL에서도 좋은 예후인자 중 하나로 제시된 적이 있으며 본 증례에서도 1차례의 관해 유도요법 후 완전관해를 보였고, t(8:21) 즉, AML1-ETO 정량 검사상 전사 정도가 현저히 감소함을 경험하였다. 특히, AML에 준한 치료만으로 성공적 관해가 유도되었으며, 이는 BAL에 있어서도 AML1-ETO 종양단백이 병태생리에 주 역할을 할 것임을 짐작할 수 있다. AML에서와 마찬가지로 AML1- ETO 유전자 재배열은 향후 BAL 환자의 치료 효과와 예후를 알 수 있는 지표로 사용될 수 있을 것이다.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
Aribi A / 2007 / Biphenotypic acute leukemia: a case series / Br J Haematol 138 : 213 ~ 216
Bene MC / 1998 / The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias / Blood 92 : 596 ~ 599
Frater JL / 2003 / Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage / Arch Pathol Lab Med 127 : 356 ~ 359
He G / 2008 / B-lymphoid and myeloid lineages biphenotypic acute leukemia with t(8;21)(q22;q22) / Int J Hematol 87 : 132 ~ 136
Jaffe ES / 2001 / Acute myeloid leukemias. In Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumours / IARC Press :
Bene MC / 1998 / The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias / Blood 92 : 596 ~ 599
Frater JL / 2003 / Biphenotypic acute leukemia with coexpression of CD79a and markers of myeloid lineage / Arch Pathol Lab Med 127 : 356 ~ 359
He G / 2008 / B-lymphoid and myeloid lineages biphenotypic acute leukemia with t(8;21)(q22;q22) / Int J Hematol 87 : 132 ~ 136
Jaffe ES / 2001 / Acute myeloid leukemias. In Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumours / IARC Press :
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