지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 231 - 238 (8page)
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초록· 키워드
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Background : AML with myelodysplasia related changes (AML MRC) is known to show a poor prognosis compared with de novo AML, but controversies exist about the prognostic impact of multilineage dysplasia (MLD) among MRC. We investigated the prognostic impact of MLD in AML MRC.
Methods : A total of 357 patients newly diagnosed as AML at Asan Medical Center from January 2001 to December 2005 were analyzed. They were diagnosed and classified as AML with recurrent genetic abnormalities, AML MRC, and AML not otherwise specified (AML NOS). Prognostic markers including overall survival (OS) and event free survival (EFS) were obtained through retrospective analysis of electronic medical records.
Results : AML MRC patients showed a lower complete remission (CR) rate (44.7% vs. 64.9%, P=0.002) and shorter OS (297 vs. 561 days, P=0.004) and EFS (229 vs. 374 days, P=0.004) than AML NOS patients. Patients with MLD among AML MRC also showed a lower CR rate (37.7%, P=0.001)and shorter OS (351 days, P=0.036) and EFS (242 days, P=0.076) than AML NOS patients. However, among AML MRC patients, there were no differences in OS, EFS and CR between patients with and without MLD.
Conclusions : AML MRC patients showed a lower CR rate and shorter OS and EFS than AML NOS patients. AML MRC patients with MLD showed similar results and their prognosis was not different from those without MLD. MLD findings among AML MRC could be an independent poor prognostic factor in de novo AML. (Korean J Lab Med 2010;30:231-8)
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Arber DA / 2003 / Prognostic impact of acute myeloid leukemia classification. Importance of detection of recurring cytogenetic abnormalities and multilineage dysplasia on sur
Bao L / 2006 / Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations / Eur J Ha
Brito-Babapulle F / 1987 / Clinical and laboratory features of de novo acute myeloid leukaemia with trilineage myelodysplasia / Br J Haematol 66 : 445 ~ 450
Cunningham I / 1989 / Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital / Blood 73 : 1116 ~ 1122
Gahn B / 1996 / De novo AML with dysplastic hematopoiesis: cytogenetic and prognostic significance / Leukemia 10 : 946 ~ 951
Bao L / 2006 / Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations / Eur J Ha
Brito-Babapulle F / 1987 / Clinical and laboratory features of de novo acute myeloid leukaemia with trilineage myelodysplasia / Br J Haematol 66 : 445 ~ 450
Cunningham I / 1989 / Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital / Blood 73 : 1116 ~ 1122
Gahn B / 1996 / De novo AML with dysplastic hematopoiesis: cytogenetic and prognostic significance / Leukemia 10 : 946 ~ 951
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