지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제36권 제4호
- 발행연도
- 2002.1
- 수록면
- 249 - 256 (8page)
이용수
초록· 키워드
오류제보하기
Inducible nitric oxide synthase (iNOS) has been detected in a number of pathologic conditions in the central nervous system. This study was investigated the patterns
of iNOS expression in the neuronal PC12 cell and the effects of nitric oxide on the apoptosis of PC12 cells. Methods : The stimulating agents for induction of iNOS expression in PC12 cells were bacterial lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-α), and interferon- gamma (IFN-γ). Results : The expression iNOS mRNA and protein in PC12 cells stimulated with LPS/TNF-α/IFN-γ were profoundly increased. The expression of iNOS mRNA arose at 6 hours, peaked at 12 hours, and declined to 48 hours after LPS/TNF-α/IFN-γ treatment. iNOS protein was increased up to 24 hours in LPS/TNF-α/IFN-γ treated PC12 cells while the expression of nNOS was unaffected. Accumulation of NO derivatives in the culture media was markedly increased at least at up to 48 hours after LPS/TNF-α/IFNtreatment. The induction of iNOS expression and NO production in differentiated PC12 cells was correlated with apoptotic cell death judged by transmission electron microscopy and DNA fragmentation from the results of the Terminal deoxynucleotidyl-transferase-mediated dUDP biotin nick end-labeling (TUNEL) method. After treatment with NOS inhibitor, Nmonomethylarginine (NMMA), a profound decrease in NO production by LPS/TNF-α/IFN-γ treated PC12 cells was noted. And the LPS/TNF-α/IFN-γ induced apoptosis was prevented by the NMMA treatment. Conclusions : From the above results it is concluded that the expression of iNOS in differentiated PC12 cells is induced by the combined application of LPS, TNF-α, and IFN-γ . And the apoptosis of cultured PC12 cells is mediated by iNOSderived NO.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Lipopolysaccharide/Interferon-gamma에 의한C6 Glioma 세포주의 Nitric Oxide 생성 양상과Dexamethasone의 억제효과
Journal of Pathology and Translational Medicine
2002 .01
-
Molecular Mechanism of NO-induced Cell Death of PC12 Cells by $IFN{\gamma}\;and\;TNF{\alpha}$
Molecular & cellular toxicology
2005 .01
-
쥐 해마의 Lipopolysaccharide 국소주입에 의한 Tumor Necrosis Factor-α, Interleukin-1β 및 Inducible Nitric Oxide Synthase의 발현
Journal of Pathology and Translational Medicine
2004 .01
-
Protein Kinase C-αRegulates Toll-like Receptor 4-Mediated Inducible Nitric Oxide Synthase Expression
대한구강악안면외과학회지
2008 .01
-
RAW 264.7 Cell에서 세이지에 의한 염증성 Cytokine 및 iNOS억제 효과
약학회지
2004 .01
-
Ginsenoside Rb1이 C6 Glioma 세포주의 Nitric Oxide 생성과 세포자멸사에 미치는 효과
Journal of Pathology and Translational Medicine
2004 .01
-
오령산가온비탕의 BV2에서 LPS로 유도된 nitric oxide 및 $TNF-{\alpha}$ 생성에 미치는 영향
대한본초학회지(본초분과학회지)
2006 .01
-
Immunohictochemical Expression of Inducible Nitric Oxide Synthase on the LPS-induced Shock and Wound Healing in Rats
해부·생물인류학
1999 .12
-
Murine macrophage RAW264.7에서 과산화수소가 유발형 산화질소 합성효소의 발현에 미치는 영향
Tuberculosis and Respiratory Diseases
1999 .01
-
Inhibitors of Inducible Nitric Oxide Synthase Expression from Artemisia iwayomogi
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2003 .01
-
The role of TNF-a in tissue-dependent production of IFN-r by LPS from macrophages.
대한약학회 학술대회
2001 .01
-
p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Regulate Nitric Oxide Production and Inflammatory Cytokine Expression in Raw Cells
Immune Network
2005 .03
-
일시적 국소 뇌허혈손상에서 신경세포의 세포자멸사와 Inducible Nitric Oxide Synthase 발현
Journal of Pathology and Translational Medicine
2004 .01
-
삼묘환(三妙丸)의 LPS에 의해 활성화된 RAW 264.7 cells과 BV-2 Microglia cells로부터 생성되는 nitric oxide 및 $TNF-{\alpha}$의 생성억제효과
대한본초학회지(본초분과학회지)
2006 .01
-
Pretreatment of Low-Dose and Super-Low-Dose LPS on the Production of In Vitro LPS-Induced Inflammatory Mediators
Toxicological Research
2018 .01
-
미세분진이 흰쥐의 폐포대식세포에서 Nitric Oxide 생성 및 iNOS 발현과 Nitrotyrosilated-protein의 형성에 미치는 효과
Tuberculosis and Respiratory Diseases
2006 .01
-
Anti-inflammatory effect of indole compound, IND-6 in LPS-stimulated RAW 264.7 murine macrophage cell line
대한약학회 학술대회
2003 .01
-
Down-regulation of inducible nitric oxide synthase and tumor necrosis factor-a expression by Bisphenol A via nuclear factor-kB inactivation in macrophages
대한약학회 학술대회
2002 .01
-
Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages.
대한약학회 학술대회
2002 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0