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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제3호
- 발행연도
- 2004.1
- 수록면
- 157 - 164 (8page)
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초록· 키워드
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Background : Brain inducible nitric oxide synthase (iNOS) might be detectable in several
pathologic conditions, and it is thought to play an important role in their pathophysiology.
Tumor necrosis factor (TNF)- and interleukin (IL)-1 are believed to be essential factors of
iNOS induction of the brain. Methods : After intrahippocampal stereotaxic injection of lipopolysaccharide
(LPS), the rat brains were removed at 6, 12 and 24 h. The rat brain tissues were
examined to clarify the expression patterns of TNF- , IL-1 and iNOS. Results : The inflammatory
cells which were stained with anti-TNF- antibody, appeared in 6 h and increased
for 24 h after LPS injection. The iNOS positive cells appeared after 12 h of LPS injection. A
semiquantitative analysis of reverse transcription-polymerase chain reaction (RT-PCR)
revealed that the TNF- and IL-1 mRNA arose at 1 h, peaked at 6 h and then declined
until 48 h after LPS injection. The iNOS mRNA arose after 6 h, peaked at 12 h, and declined
until 48 h after LPS injection. Conclusions : We conclude that the induction of inflammatory
events by intrahippocampal injection of LPS activates TNF- and IL-1 secretion, and this
is followed by an induction of iNOS expression. TNF- and IL-1 seem to be related with
iNOS expression in brain inflammation.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Arimoto T / 2003 / Up-regulation of inducible nitric oxide synthase in the substantia nigra by lipopolysaccharide causes microglial activation and neurodegeneration. / Neuro
Bagasra O / 1995 / Activation of the inducible form of nitric oxide synthase in the brains of patients with multiples sclerosis. / Proc Natl Acad Sci USA 92
Bredt D.S / 1990 / Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. / Proc Natl Acad Sci USA 87 : 682 ~ 685
Dawson T.M / 1994 / Gases as biological messengers: nitric oxide and carbon monoxide in the brain. / J Neurosci 14 : 5147 ~ 5159
Dawson T.M / 1994 / Nitric oxide: cellular regulation and neuronal injury. / Prog Brain Res 103 : 365 ~ 369
Bagasra O / 1995 / Activation of the inducible form of nitric oxide synthase in the brains of patients with multiples sclerosis. / Proc Natl Acad Sci USA 92
Bredt D.S / 1990 / Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. / Proc Natl Acad Sci USA 87 : 682 ~ 685
Dawson T.M / 1994 / Gases as biological messengers: nitric oxide and carbon monoxide in the brain. / J Neurosci 14 : 5147 ~ 5159
Dawson T.M / 1994 / Nitric oxide: cellular regulation and neuronal injury. / Prog Brain Res 103 : 365 ~ 369
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