지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제50권 제5호
- 발행연도
- 2016.1
- 수록면
- 361 - 368 (8page)
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Background: CD99 is a cell surface transmembrane glycoprotein expressed in various tissues. CD99 is differentially expressed between subpopulations of each tissue and is highly expressed in certain hematopoietic and precursor cells. However, there has been no comprehensive study of CD99 expression in normal skin. We evaluated CD99 expression in normal human skin and developing fetal skin. Methods: Seventy-five adult skin samples containing normal skin and eight fetal skin samples of different gestational ages were collected. CD99 immunohistochemical staining was performed to evaluate expression pattern in adult and fetal skin samples. CD99 and CD34 expression were compared by double immunofluorescence. Results: In normal adult skin, CD99 was strongly expressed in the membrane of epidermal basal keratinocytes, hair follicle bulges and outer root sheaths, and inner secretory cells of eccrine sweat glands. In fetal skin, CD99 was not expressed on the periderm at 16 weeks of gestation but was expressed in basal cells of fetal skin at around 19 weeks of gestation. CD99 expression became comparable to that of the adult skin after 20 weeks of gestation. CD99 and CD34 were co-expressed in hair follicle outer root sheaths, as seen by double immunofluorescence study. Conclusions: This is the first study examining CD99 expression pattern in normal adult and fetal skin. CD99 tends to be expressed in the basal/precursor cells of epidermis and in hair follicles. These results provide a basis for future investigation on functions of CD99 in the skin and provide a novel potential target for the treatment of dermatologic lesions.
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참고문헌 (24)
참고문헌 신청
Aussel C / 1993 / Monoclonal antibodies directed against the E2 protein (MIC2 gene product) induce exposure of phosphatidylserine at the thymocyte cell surface / Biochemistry 32:10096~10101
Dworzak MN / 1994 / cytometric assessment of human MIC2 expression in bone marrow, thymus, and peripheral blood / Blood 83:415~425
Gordon MD / 1998 / CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis / Mod Pathol 11:769~773
Strauchen JA / 2003 / Lymphoid progenitor cells in human tonsils / Int J Surg Pathol 11:21~24
Bernard G / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4+ CD8+ thymocytes / J Immunol 154:26~32
Dworzak MN / 1994 / cytometric assessment of human MIC2 expression in bone marrow, thymus, and peripheral blood / Blood 83:415~425
Gordon MD / 1998 / CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis / Mod Pathol 11:769~773
Strauchen JA / 2003 / Lymphoid progenitor cells in human tonsils / Int J Surg Pathol 11:21~24
Bernard G / 1995 / The E2 molecule (CD99) specifically triggers homotypic aggregation of CD4+ CD8+ thymocytes / J Immunol 154:26~32
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