지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제4호
- 발행연도
- 2021.1
- 수록면
- 377 - 383 (7page)
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초록· 키워드
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Purpose: We investigated the association of effector memory (EM) CD8+ T cell and CD4+ T cell immunity with metabolic syndrome (MS). Methods: Surface and intracellular staining of peripheral blood mononuclear cells was performed. Anti-interleukin-7 receptor-alpha (IL-7Rα) and CX3CR1 antibodies were used to stain the subsets of EM CD8+ T cells, while anti-interferon-gamma (IFN-γ), interleukin-17 (IL-17), and forkhead box P3 (FOXP3) antibodies were used for CD4+ T cell subsets. Results: Of the 47 obese children, 11 were female. Children with MS had significantly higher levels of serum insulin (34.8±13.8 vs. 16.4±6.3 μU/mL, p<0.001) and homeostasis model assessment of insulin resistance (8.9±4.1 vs. 3.9±1.5, p<0.001) than children without MS. Children with MS revealed significantly higher frequencies of IL-7Rαlow CD8+ T cells (60.1 ±19.1% vs. 48.4±11.5%, p=0.047) and IL-7RαlowCX3CR1+ CD8+ T cells (53.8±20.1% vs. 41.5 ±11.9%, p=0.036) than children without MS. As the serum triglyceride levels increased, the frequency of IL-7RαlowCX3CR1+ and IL-7RαhighCX3CR1? CD8+ T cells increased and decreased, respectively (r=0.335, p=0.014 and r=?0.350, p=0.010, respectively), in 47 children. However, no CD4+ T cell subset parameters were significantly different between children with and without MS. Conclusion: In obese children with MS, the changes in immunity due to changes in EM CD8+ T cells might be related to the morbidity of obesity.
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참고문헌 (4)
참고문헌 신청
강기수 / 2017 / Nutritional Counseling for Obese Children with Obesity-Related Metabolic Abnormalities in Korea / Pediatric Gastroenterology, Hepatology & Nutrition 20(2):71~78
Helen H. Wang / 2020 / Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome / Pediatric Gastroenterology, Hepatology & Nutrition 23(3):189~230
Min-Su Oh / 2016 / Associations among the Degree of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity / Pediatric Gastroenterology, Hepatology & Nutrition 19(3):199~206
Min-Su Oh / 2020 / Factors associated with Advanced Bone Age in Overweight and Obese Children / Pediatric Gastroenterology, Hepatology & Nutrition 23(1):89~97
Helen H. Wang / 2020 / Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome / Pediatric Gastroenterology, Hepatology & Nutrition 23(3):189~230
Min-Su Oh / 2016 / Associations among the Degree of Nonalcoholic Fatty Liver Disease, Metabolic Syndrome, Degree of Obesity in Children, and Parental Obesity / Pediatric Gastroenterology, Hepatology & Nutrition 19(3):199~206
Min-Su Oh / 2020 / Factors associated with Advanced Bone Age in Overweight and Obese Children / Pediatric Gastroenterology, Hepatology & Nutrition 23(1):89~97
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