메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Daniéla Oliveira Magro (State University of Campinas) Paulo Gustavo Kotze (Cajuru University Hospital) Carlos Augusto Real Martinez (State University of Campinas) Michel Gardere Camargo (State University of Campinas) Dioze Guadagnini (State University of Campinas) Antonio Ramos Calixto (State University of Campinas) Ana Carolina Junqueira Vasques (State University of Campinas) Maria de Lourdes Setsuko Ayrizono (State University of Campinas) Bruno Geloneze (State University of Campinas) José Carlos Pareja (State University of Campinas) Mario José Saad (State University of Campinas) Claudio Saddy Rodrigues Coy (State University of Campinas)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.15 No.3
발행연도
2017.1
수록면
352 - 357 (6page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: Lipopolysaccharide (LPS) is a molecule formed by lipids and polysaccharides and is the major cell wallcomponent of gram-negative bacteria. High LPS levels are known to block CD26 expression by activating Toll-like receptor 4. The aim of this study was to correlate the serum levels of LPS and CD26 in Crohn’s disease (CD) patients with serum levelsof C-reactive protein (CRP), interleukins, CD activity index, and tumor necrosis factor-α (TNF-α). Methods: Serum sampleswere collected from 27 individuals (10 with active CD, 10 with inactive CD, and 7 controls) and the levels of LPS, CD26, TNF-α,interleukin-1β (IL-1β), IL-6, IL-17, and CRP were determined by enzyme-linked immunosorbent assay. The levels of LPS andCD26 were then tested for correlation with TNF-α, IL-1β, IL-6, IL-17, and CRP. Results: Serum levels of LPS were significantlyelevated in the active CD group (P =0.003). Levels of IL-1β (P =0.002), IL-6 (P =0.003), and IL-17 (P <0.001) were lower in theCD groups. Serum TNF-α levels were increased in the active CD group. The CRP levels were elevated in the CD groups whencompared to controls (P <0.001). The CD26 levels were lower in the CD groups than in the control group (P <0.001). Among thevariables analyzed, there was a correlation between LPS and CRP (r=–0.53, P =0.016) in the CD groups. Conclusions: Individualswith CD exhibited higher serum levels of LPS varying from a 2- to 6-fold increase depending on disease activity, when comparedwith healthy controls. CD26 levels were lower in the CD groups. Both LPS and CD26 correlated with disease severity andserve as potential CD biomarkers.

목차

등록된 정보가 없습니다.

참고문헌 (23)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0