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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제44권 제5호
- 발행연도
- 2010.1
- 수록면
- 462 - 468 (7page)
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초록· 키워드
오류제보하기
Background : Osteopontin (OPN) is a cytokine related to cell-matrix adhesion and cell survival and is expressed in the distal convoluted tubules in normal adult kidneys. Only one in vitro study has investigated the role of OPN in mechanically stretched podocytes and their actin cytoskeleton rearrangement. Methods : Glomerular OPN expression was investigated in biopsies from patients with human idiopathic focal segmental glomerulosclerosis (FSGS) (n = 25) and in normal renal biopsies (n = 16) by immunohistochemistry. Results : OPN was expressed in the podocytes from patients with FSGS. OPN expression increased in podocytes from both non-sclerotic hypertrophic and sclerotic glomerular tufts in patients with FSGS compared to the podocytes in normal controls. Conclusions : The results suggest that OPN plays a role in the early adaptive response of podocytes to the increased mechanical load caused by glomerular hypertrophy preceding FSGS. OPN was involved in cell-matrix adhesion and influenced the detachment delay of podocytes from the glomerular basement membrane and apoptosis.
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참고문헌 (25)
참고문헌 신청
[학
Bennett MR / 2007 / Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli / Nephron Exp Nephrol 107 : e30 ~ e40
Denhardt DT / 1995 / Osteopontin-induced modifications of cellular functions / Ann N Y Acad Sci 760 : 127 ~ 142
Denhardt DT / 2001 / Osteopontin as a means to cope with environmental insults:regulation of inflammation,tissue remodeling,and cell survival / J Clin Invest 107 : 1055 ~ 10
D’Agati VD / 2008 / The spectrum of focal segmental glomerulosclerosis:new insights / Curr Opin Nephrol Hypertens 17 : 271 ~ 281
Bennett MR / 2007 / Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli / Nephron Exp Nephrol 107 : e30 ~ e40
Denhardt DT / 1995 / Osteopontin-induced modifications of cellular functions / Ann N Y Acad Sci 760 : 127 ~ 142
Denhardt DT / 2001 / Osteopontin as a means to cope with environmental insults:regulation of inflammation,tissue remodeling,and cell survival / J Clin Invest 107 : 1055 ~ 10
D’Agati VD / 2008 / The spectrum of focal segmental glomerulosclerosis:new insights / Curr Opin Nephrol Hypertens 17 : 271 ~ 281
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