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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제40권 제3호
- 발행연도
- 2006.1
- 수록면
- 225 - 230 (6page)
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초록· 키워드
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Background : Osteopontin (OPN) is a glycoprotein and it participates in cell-cell and cell-matrix interactions. In vitro studies suggest that the OPN expression is associated with tumor metastasis,
and especially with the metastasis of osteotropic tumors originating in breast, prostate and lungs. Since no human tissue study has suggested the means by which OPN participates in the tumorigenesis, angiogenesis, progression and metastasis of renal cell carcinoma (RCC), we evaluated the expression and prognostic significance of OPN in RCC. Methods : Immunohistochemistry was performed with using the primary antibody for OPN on the archival paraffin-embedded tissue microarray specimens from 51 RCC patients who underwent radical or simple nephrectomy. Results : In the normal kidney specimens, OPN was expressed in a few compressed distal tubules adjacent to the RCCs. In RCCs, the OPN expression was elevated in larger tumors (p<0.05) and in the tumor with low microvessel density (p<0.01). In the
present study, univariate analysis indicated that stage, tumor size, lymph node and distant organ metastasis are significant prognostic factors for disease free survival (DFS) in RCC patients (p<0.01), but OPN is not (p=0.0661). Multivariate analysis indicated lymph node metastasis
is the independent prognostic indicator of DFS (p<0.05). Conclusion : Though this study has statistical limitations, these results suggest OPN plays a role in tumor progression and metastasis and it may act as a potential prognostic indicator to predict the prognosis of RCC patients.
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참고문헌 (27)
참고문헌 신청
/ / Induction of expression of osteopontin : 43 ~ 7
/ 1979 / Transformed mammalian cellssecrete specific proteins and phosphoproteins 16 : 885 ~ 93
/ 1992 / Expression and distribution of osteopontin in human tissues:widespread association with luminal epithelial cell surfaces 3 : 1169 ~ 80
/ 1994 / Osteopontin expression and distribution in human carcinomas 145 : 610 ~ 623
/ 1995 / Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity cor
/ 1979 / Transformed mammalian cellssecrete specific proteins and phosphoproteins 16 : 885 ~ 93
/ 1992 / Expression and distribution of osteopontin in human tissues:widespread association with luminal epithelial cell surfaces 3 : 1169 ~ 80
/ 1994 / Osteopontin expression and distribution in human carcinomas 145 : 610 ~ 623
/ 1995 / Identification of a ras-activated enhancer in the mouse osteopontin promoter and its interaction with a putative ETS-related transcription factor whose activity cor
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