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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제4호
- 발행연도
- 2018.1
- 수록면
- 226 - 231 (6page)
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초록· 키워드
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Hepatocellular adenoma (HCA) is the most common type of benign liver tumor, and its major complication is malignant transformation to hepatocellular carcinoma (HCC). Here, we report a case of HCC arising in HCA with bone marrow metaplasia in a 24-year-old Korean woman who presented with abdominal discomfort. A huge liver mass was found on abdominal ultrasonography. She underwent surgical hepatic resection, and the resected specimen was entirely involved by a 20-cm-sized tumor. Histological review revealed a well differentiated HCC arising from inflammatory HCA with β-catenin nuclear positivity and bone marrow metaplasia that contained hematopoietic cells. This case was unique because malignant transformation, inflammatory type HCA, β-catenin nuclear staining, and bone marrow metaplasia were simultaneously observed. Additionally, it should be noted that a large HCA with β-catenin activation can undergo malignant transformation and should be surgically resected in a timely manner.
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참고문헌 (20)
참고문헌 신청
Chang CY / 2013 / Changing epidemiology of hepatocellular adenoma in the United States: review of the literature / Int J Hepatol 2013:604860
Bioulac-Sage P / 2017 / Hepatocellular adenoma: classification, variants and clinical relevance / Semin Diagn Pathol 34:112~125
Bioulac-Sage P / 2010 / Subtype classification of hepatocellular adenoma / Dig Surg 27:39~45
Margolskee E / 2016 / Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis / Diagn Pathol 11:27
Chu HH / 2013 / ${\beta}$ -catenin activated hepatocellular adenoma / Clin Mol Hepatol 19:185~189
Bioulac-Sage P / 2017 / Hepatocellular adenoma: classification, variants and clinical relevance / Semin Diagn Pathol 34:112~125
Bioulac-Sage P / 2010 / Subtype classification of hepatocellular adenoma / Dig Surg 27:39~45
Margolskee E / 2016 / Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis / Diagn Pathol 11:27
Chu HH / 2013 /
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