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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 107 - 114 (8page)
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Inflammatory bowel disease (IBD) is a chronic inflammatory disorder on the large intestine that has been considered as an incurable not only in Western society but also in Eastern Asia in recent years. Despite enormous efforts to develop novel therapeutics for this disease, strategy using bioactive compounds from natural product is still considered as important. p-hydroxycinnamic acid (HCA) is an intermediate substance found in several plants and has been known to possess anti-inflammation but little evidence is reported whether HCA has an inhibitory effect on intestinal inflammation. In the present study, we observed HCA does not show cytotoxic and apoptotic in HT-29 cells. Quantitative PCR analysis revealed that HCA effectively blocks the activity of HT-29 cells stimulated with TNF-α treatment. HCA inhibits translocation of p65 and MAPK pathways in activated HT-29 cells by TNF-α treatment. Besides, oral administration of HCA attenuates manifestation of DSS-induced inflammatory disease in vivo. Histological analysis exhibited that oral administration of HCA recovers IBD symptoms. The expression of pro-inflammatory cytokines were reduced by oral administration of HCA on intestinal tissues. Therefore, these results suggest that HCA has a potent anti-inflammatory effect on intestinal cells as well as show a therapeutic potential for treating IBD in vivo.
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Abstract
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참고문헌 (16)
참고문헌 신청
Choi, E. J. / 2019 / Enterococcus faecalis EF-2001protects DNBS-induced inflammatory bowel disease in mice model / PLoS One 14:e0210854
Kaser, A. / 2010 / Inflammatory Bowel Disease / Annu. Rev. Immunol 28:573~621
Horsthuis, K. / 2008 / Detection of inflammatory bowel disease : Diagnostic performance of cross-sectional imaging modalities / Abdom. Imaging 33:407~416
Baumgart, D. C. / 2007 / Inflammatory bowel disease : clinical aspects and established and evolving therapies / Lancet 369:1641~1657
Moldoveanu, A. C. / 2015 / Cytokines in inflammatory bowel disease / Rom. J. Intern. Med 53:118~127
Kaser, A. / 2010 / Inflammatory Bowel Disease / Annu. Rev. Immunol 28:573~621
Horsthuis, K. / 2008 / Detection of inflammatory bowel disease : Diagnostic performance of cross-sectional imaging modalities / Abdom. Imaging 33:407~416
Baumgart, D. C. / 2007 / Inflammatory bowel disease : clinical aspects and established and evolving therapies / Lancet 369:1641~1657
Moldoveanu, A. C. / 2015 / Cytokines in inflammatory bowel disease / Rom. J. Intern. Med 53:118~127
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