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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제6호
- 발행연도
- 2018.1
- 수록면
- 357 - 362 (6page)
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초록· 키워드
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Background: The up-regulation of the lipogenic pathway has been reported in many types of malignant tumors. However, its pathogenic role or clinical significance is not fully understood. The objective of this study was to examine the expression levels of adipophilin and related hypoxic signaling proteins and to determine their prognostic impacts and associations with the pathologic characteristics of lung adenocarcinoma. Methods: Expression levels of adipophilin, heat shock protein 27 (HSP27), carbonic anhydrase IX, and hypoxia-inducible factor 1α were examined by immunohistochemical staining using tissue microarray blocks. Correlations between protein expression levels and various clinicopathologic features were analyzed. Results: A total of 230 cases of primary adenocarcinoma of the lung were enrolled in this study. Adipophilin expression was more frequent in males and with the solid histologic type. It was correlated with HSP27 expression. Patients with adipophilin-positive adenocarcinoma showed a shorter progression-free survival (PFS) (median PFS, 17.2 months vs 18.4 months) in a univariable survival analysis, whereas HSP27 positivity correlated with favorable overall survival (OS) and PFS. In a multivariable analysis, adipophilin and HSP27 were independent prognostic markers of both OS and PFS. Conclusions: Activated lipid metabolism and the hypoxic signaling pathway might play a major role in the progression of lung adenocarcinoma, especially in the solid histologic type.
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참고문헌 (17)
참고문헌 신청
Hsu PP / 2008 / Cancer cell metabolism: Warburg and beyond / Cell 134:703~707
Beloribi-Djefaflia S / 2016 / Lipid metabolic reprogramming in cancer cells / Oncogenesis 5:e189
Alo PL / 1996 / Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients / Cancer 77:474~482
Camassei FD / 2003 / Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness / Invest Ophthalmol Vis Sci 44:2399~2403
Migita T / 2008 / ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer / Cancer Res 68:8547~8554
Beloribi-Djefaflia S / 2016 / Lipid metabolic reprogramming in cancer cells / Oncogenesis 5:e189
Alo PL / 1996 / Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients / Cancer 77:474~482
Camassei FD / 2003 / Expression of the lipogenic enzyme fatty acid synthase (FAS) in retinoblastoma and its correlation with tumor aggressiveness / Invest Ophthalmol Vis Sci 44:2399~2403
Migita T / 2008 / ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer / Cancer Res 68:8547~8554
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