지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1,497 - 1,502 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Heat shock proteins (HSPs) are highly conserved molecular chaperones. There are various studies that assess the prognosticvalue of HSPs in patients with esophageal cancer, but the conclusion remains controversial. This is the first meta-analysisstudy aiming to summarize the evidence on the suitability of HSPs to predict patients’ survival.
Materials and Methods: Searching PubMed, Web of science and Medline until May 31, 2014, data were compared for overall survivalin patients with down-regulated HSPs level with those with up-regulated level. We conducted a meta-analysis of 9 studies(801 patients) that correlated HSPs levels with overall survival. Data were synthesized with hazard ratios (HRs).
Results: The estimated risk of death was 2.93-fold greater in HSP27 negative patients than HSP27 positive patients [95% confidenceinterval (CI), 1.12–7.62]. When limited to esophageal squamous cell carcinoma (ESCC), the risk of death in HSP27 negativepatients seemed more significant (HR, 3.90; 95% CI, 2.35–6.49). Decreased expression of HSP70 was also associated with worsesurvival in esophageal cancer (HR, 2.83; 95% CI, 1.90–4.23) and, when limited to ESCC, HR was 3.21 (95% CI, 1.94–5.30). Data collected,however, were not sufficient to determine the prognostic value of HSP90 in patients with ESCC nor esophageal adenocarcinomas(EADC).
Conclusion: In this meta-analysis, reduced HSP27 and HSP70 expressions were associated with poor survival in patients withesophageal cancer, especially esophageal squamous cell carcinoma.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Argon Y / 1999 / GRP94, an ER chaperone with protein and peptide binding properties / Semin Cell Dev Biol 10 : 495 ~ 505
Berg D / 2011 / Discovery of new molecular subtypes in oesophageal adenocarcinoma / PLoS One 6 : e23985 ~
Chen M / 2012 / Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer: a systematic review and meta-analysis / Cancer Epidemiol
Ciocca DR / 2005 / Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications / Cell Stress Chaperones 10 : 86 ~ 103
Delektorskaya VV / 2010 / Squamous cell carcinoma of the esophagus: evaluation of the status of epidermal growth factor receptors (EGFR and HER-2) by immunohistochemistry and
Berg D / 2011 / Discovery of new molecular subtypes in oesophageal adenocarcinoma / PLoS One 6 : e23985 ~
Chen M / 2012 / Prognostic value of vascular endothelial growth factor expression in patients with esophageal cancer: a systematic review and meta-analysis / Cancer Epidemiol
Ciocca DR / 2005 / Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications / Cell Stress Chaperones 10 : 86 ~ 103
Delektorskaya VV / 2010 / Squamous cell carcinoma of the esophagus: evaluation of the status of epidermal growth factor receptors (EGFR and HER-2) by immunohistochemistry and
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Heat Shock Protein 90 (HSP90) and Immune Regulation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
-
Differential Expression of HSP90𝛽 in MDA-MB-231 and MCF-7 Cell Lines after Treatment with Doxorubicin
Journal of Pharmacopuncture
2019 .01
-
Transcriptional responses of heat shock protein 90 (HSP90) and heat shock protein 83 (HSP83) genes by salinity changes in the intertidal crab Macrophthalmus japonicus
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
2',4'-Dimethoxychalcone 유도체 합성 및 비소폐암세포주에서 항암 활성평가
약학회지
2016 .01
-
Studies on the Mechanism of HSP90 Inhibitors in Colorectal Cancer
대한외과학회 학술대회 초록집
2018 .11
-
Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage
Investigative and Clinical Urology
2015 .01
-
Thermal Injury Induces Small Heat Shock Protein in the Optic Nerve Head In Vivo
Korean Journal of Ophthalmology
2021 .12
-
Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-Schӧnlein Purpura in Korea
Journal of Korean Medical Science
2018 .01
-
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer
Journal of Breast Cancer
2015 .01
-
Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells
Journal of Veterinary Science
2017 .06
-
The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells
Journal of Veterinary Science
2016 .03
-
Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid
Annals of Dermatology
2017 .01
-
Small Molecule Inhibitors toDisrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
대한암예방학회지
2015 .01
-
Synergistic induction of anticancer activity by a novel HSP90 inhibitor NXD30020 combined therapy with chemotherapy through an apoptotic process in Her2 positive gastric cancer
한국실험동물학회 학술발표대회 논문집
2016 .02
-
The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy
Journal of Korean Medical Science
2015 .01
-
Architecture Design of Healthcare Software-as-a- Service Platform for Cloud-Based Clinical Decision Support Service
Healthcare Informatics Research
2015 .01
-
Proposal of Dual Inhibitor Targeting ATPase Domains of Topoisomerase II and Heat Shock Protein 90
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II
Electrolytes & Blood Pressure
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0