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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 196 - 203 (8page)
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초록· 키워드
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Background and Purpose:Alzheimer’s disease (AD) is associated with structural alterations in the medial temporal lobe (MTL) and functional alterations in the posterior cortical region, especially in the early stages. However, it is unclear what mechanisms underlie these regional discrepancies or whether the posterior cortical hypometabolism reflects disconnection from the MTL lesion or is the result of local pathology. The precuneus, an area of the posteromedial cortex that is involved in the early stages of AD, has recently received a great deal of attention in functional neuroimaging studies. To assess the relationship between the precuneus and hippocampus in AD, we investigated the volumes of these two areas using a magnetic resonance volumetric method.
Methods: Twenty-three subjects with AD and 14 healthy age-matched controls underwent T1-weighted three-dimensional volumetric brain magnetic resonance imaging. Volumetric measurements were performed in the precuneus and hippocampus.
Results: Compared to controls, AD patients exhibited a significant reduction in total precuneal volume, which was more prominent on the right side, and significant bilateral reductions in hippocampal volume. No correlation was found between the total volumes of the precuneus and hippocampus in the AD group.
Conclusions: These results suggest that volumetric measurements of both the precuneus and hippocampus are useful radiological indices for the diagnosis of AD. Furthermore, the lack of correlation is attributable to local pathology rather than being a secondary consequence of MTL pathology.
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참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)]
Ashburner J / 2000 / Voxel-based morphometry--the methods / Neuroimage 11 : 805 ~ 821
Ashburner J / 2001 / Why voxel-based morphometry should be used / Neuroimage 14 : 1238 ~ 1243
Baron JC / 2001 / In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease / Neuroimage 14 : 298 ~ 309
Cavanna AE / 2006 / The precuneus:a review of its functional anatomy and behavioural correlates / Brain 129 : 564 ~ 583
Ashburner J / 2000 / Voxel-based morphometry--the methods / Neuroimage 11 : 805 ~ 821
Ashburner J / 2001 / Why voxel-based morphometry should be used / Neuroimage 14 : 1238 ~ 1243
Baron JC / 2001 / In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer’s disease / Neuroimage 14 : 298 ~ 309
Cavanna AE / 2006 / The precuneus:a review of its functional anatomy and behavioural correlates / Brain 129 : 564 ~ 583
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