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논문 기본 정보

자료유형
학술저널
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대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제12권 제4호
발행연도
2016.1
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414 - 418 (5page)

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Background and Purpose Regular exercise can result in changes in the levels of oxidative stress in the hippocampus; however, little attention has been paid to physical-activity-induced neuronal protection to exposure to lead compounds. This study investigated the effects of regular treadmill exercise on a DNA oxidative-damage marker [8-hydroxy-2’-deoxyguano¬sine (8-OHdG)] and the total antioxidant capacity (TAC) of hippocampal tissue in lead-ace¬tate exposed rats. Methods This study investigated the effects of 8 weeks of regular treadmill exercise on 8-OHdG and the TAC of hippocampal tissue in lead-acetate-exposed rats. Wistar rats were randomly divided into four groups: baseline, sham (control), lead, and exercise+lead. The ex¬ercise program involved running on a treadmill with increasing intensity five times a week for 8 weeks. Animals in the lead and exercise+lead groups received lead acetate at 20 mg/kg body weight intraperitoneally three times weekly for 8 weeks. Animals in the sham group re¬ceived solvent (ethyl oleate) at 30 mg/kg body weight three times weekly for 8 weeks. TAC and 8-OHdG were measured by spectrophotometric and ELISA techniques, respectively. Data were analyzed by ANOVA and Tukey’s post-hoc test with a significance cutoff of p≤0.05. Results The level of 8-OHdG and the TAC were significantly higher and lower, respective¬ly, in the lead group than in the baseline and sham groups (p<0.01). However, the 8-OHdG level and TAC value in hippocampal tissue were significantly decreased and increased, re-spectively, in the exercise+lead group relative to the lead group (p<0.05). Conclusions The TAC of hippocampal tissue may be directly associated with neural protec¬tion mechanisms of exercise following lead acetate injection, and the beneficial effects of regular exercise in preventing hippocampal neuronal damage could be due to decreased hippocampal oxidative stress such as reflected by a lower 8-OHdG level and increased TAC.
#regular treadmill exercise #total antioxidant capacity #8-OHdG #hippocampus #lead acetate #oxidative stress

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참고문헌 (22)

참고문헌 신청
Roceri M / 2002 / Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus / Mol Psychiatry 7:609~616 google schola White LD / 2007 / New and evolving concepts in the neurotoxicology of lead / Toxicol Appl Pharmacol 225:1~27 google schola Dabidi RV / 2013 / Endurance exercise training and diferuloyl methane supplement:changes in neurotrophic factor and oxidative stress induced by lead in rat brain / Biol Sport 30:41~46 google schola Hosseinzadeh S / 2013 / Continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats / Pharm Biol 51:240~245 google schola Cechetti F / 2007 / Effect of treadmill exercise on cell damage in rat hippocampal slices submitted to oxygen and glucose deprivation / Brain Res 1157:121~125 google schola

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