지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.6
- 발행연도
- 2017.6
- 수록면
- 402 - 410 (9page)
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초록· 키워드
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Purpose: This study aims to examine and compare the effects of immunosuppressant cyclosporine A (CsA) and tacrolimus (TAC) on colon anastomosis recovery.
Methods: Forty rats were randomly divided into 4 groups. The 4 groups were determined as follows: control group; sham group, given %0.09 NaCl; TAC group, given 0.5 mg/kg/day tacrolimus; and CsA group, given 5 mg/kg/day CsA. A 6-cm midabdomen incision was performed on the rats. An incision of all layers on the right colon was performed. Then anastomosis was undertaken. Laparotomy was performed on the seventh day postoperation. The colon bursting pressures were evaluated, histopathological examinations were undertaken, and E-cadherin expression and tissue hydroxyproline levels were evaluated.
Results: Statistically significant differences were observed among bursting pressures of the groups (P < 0.001). The value was significantly low in TAC and CsA groups when compared to control and sham groups (P < 0.05). The tissue hydroxyproline levels were significantly low in TAC group compared to control group (P = 0.03). Fibroblast density and neovascularization were significantly greater in the control group compared to the TAC group (P < 0.05). Levels of collagen had decreased significantly in TAC group compared to other groups (P < 0.05).
Conclusion: Our study showed that TAC may have a negative effect of colon anastomosis recovery. The lowest anastomosis bursting pressure was detected in TAC group. Also, collagen, hydroxyproline, fibroblast, neovascularization and E-Cadherin levels were comparatively lower in TAC group. CsA did not cause any significant changes to tissue hydroxyproline, collagen, fibroblast, and E-Cadherin levels.
Methods: Forty rats were randomly divided into 4 groups. The 4 groups were determined as follows: control group; sham group, given %0.09 NaCl; TAC group, given 0.5 mg/kg/day tacrolimus; and CsA group, given 5 mg/kg/day CsA. A 6-cm midabdomen incision was performed on the rats. An incision of all layers on the right colon was performed. Then anastomosis was undertaken. Laparotomy was performed on the seventh day postoperation. The colon bursting pressures were evaluated, histopathological examinations were undertaken, and E-cadherin expression and tissue hydroxyproline levels were evaluated.
Results: Statistically significant differences were observed among bursting pressures of the groups (P < 0.001). The value was significantly low in TAC and CsA groups when compared to control and sham groups (P < 0.05). The tissue hydroxyproline levels were significantly low in TAC group compared to control group (P = 0.03). Fibroblast density and neovascularization were significantly greater in the control group compared to the TAC group (P < 0.05). Levels of collagen had decreased significantly in TAC group compared to other groups (P < 0.05).
Conclusion: Our study showed that TAC may have a negative effect of colon anastomosis recovery. The lowest anastomosis bursting pressure was detected in TAC group. Also, collagen, hydroxyproline, fibroblast, neovascularization and E-Cadherin levels were comparatively lower in TAC group. CsA did not cause any significant changes to tissue hydroxyproline, collagen, fibroblast, and E-Cadherin levels.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Willems MC / 2013 / Tacrolimus does not affect early wound healing in a rodent model of bowel anastomoses and abdominal wall closure / PLoS One 8 : e76348 ~
[학술지(정기간행물)] - Seyhun Y / 2015 / Genetic association of interleukin-2, interleukin-4, interleukin-6, transforming growth factor-b, tumour necrosis factor-a and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients / Int J Immunogenet 42 : 147 ~ 160
[학술지(정기간행물)] - Chung BH / 2012 / Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression / PLoS One 7 : e42011 ~
[학술지(정기간행물)] - Kita J / 1999 / Effects of tacrolimus on small and large bowel anastomoses in the rat / Transplant Proc 31 : 2789 ~
[학술지(정기간행물)] - Willems MC / 2010 / Persistent effects of everolimus on strength of experimental wounds in intestine and fascia / Wound Repair Regen 18 : 98 ~ 104
[학술지(정기간행물)] - Seyhun Y / 2015 / Genetic association of interleukin-2, interleukin-4, interleukin-6, transforming growth factor-b, tumour necrosis factor-a and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients / Int J Immunogenet 42 : 147 ~ 160
[학술지(정기간행물)] - Chung BH / 2012 / Dysregulation of Th17 cells during the early post-transplant period in patients under calcineurin inhibitor based immunosuppression / PLoS One 7 : e42011 ~
[학술지(정기간행물)] - Kita J / 1999 / Effects of tacrolimus on small and large bowel anastomoses in the rat / Transplant Proc 31 : 2789 ~
[학술지(정기간행물)] - Willems MC / 2010 / Persistent effects of everolimus on strength of experimental wounds in intestine and fascia / Wound Repair Regen 18 : 98 ~ 104
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UCI(KEPA) : I410-ECN-0101-2018-514-000894953