지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 242 - 248 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaAtypical antipsychotic (AAP) treatment is associated with weight gain and metabolic disturbances such as dyslipidemia and dysglycemia. The metabolic disturbances are usually considered to develop secondary to weight gain. We performed the comparison of metabolic disturbances of three AAP group with different risk of metabolic side effect after adjusting for body mass to investigate whether any metabolic disturbances develop independently from body mass index (BMI).
MethodsaaThis cross-sectional study included 174 subjects with schizophrenia who were on 1) monotherapy with clozapine (CL), olanzapine (OL), or quetiapine (QT) (n=61), 2) monotherapy with risperidone (RSP) (n=89), or 3) monotherapy with aripiprizole (ARP), or ziprasidone (ZPS) (n=24) more than 1 year. Association between the prevalence of metabolic disturbances and groups were analysed using logistic regression after adjusting confounding variables including BMI. Analysese of covariance were used to compare the AAP groups in terms of the levels of metabolic parameters.
ResultsaaThere were significant differences among groups in terms of the prevalence of hypertriglyceridemia (p=0.015), low HDL-cholesterol (p=0.017), and hyperglycemia (p=0.022) after adjusting for BMI. Triglyceride level (p=0.014) and the ratio of triglyceride to HDL-cholesterol (p=0.004) were significantly different among groups after adjusting for BMI.
ConclusionaaIn conclusion, metabolic disturbances are significantly different in AAP groups even after adjusting BMI. AAPs may have direct effect on metabolic parameters. Blood lipid and glucose levels should be monitored regularly regardless of whether patients tend to gain weight.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Atmaca M / 2003 / Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics / J Clin Psychiatry 64 : 598 ~ 604
De Hert M / 2011 / Metabolic and cardiovascular adverse effects associated with antipsychotic drugs / Nat Rev Endocrinol 8 : 114 ~ 126
Grundy SM / 2005 / Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung, and Blood Institute scientific statement / Circulat
Haupt DW / 2006 / Differential metabolic effects of antipsychotic treatments / Eur Neuropsychopharmcol 16 (Suppl 3) : S149 ~ S155
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157 : 975 ~ 981
De Hert M / 2011 / Metabolic and cardiovascular adverse effects associated with antipsychotic drugs / Nat Rev Endocrinol 8 : 114 ~ 126
Grundy SM / 2005 / Diagnosis and management of the metabolic syndrome an American Heart Association/National Heart, Lung, and Blood Institute scientific statement / Circulat
Haupt DW / 2006 / Differential metabolic effects of antipsychotic treatments / Eur Neuropsychopharmcol 16 (Suppl 3) : S149 ~ S155
Henderson DC / 2000 / Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study / Am J Psychiatry 157 : 975 ~ 981
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