Effects of sulfur dioxide, ozone, and ambient air pollution on bone metabolism related biochemical parameters in a rat model

Sorayya Kheirouri; Mohammad Alizadeh; Razieh Musapour Sultan Abad; Sona Barkabi-Zanjani; Mehran Mesgari-Abbasi

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저자정보: Sorayya Kheirouri (Tabriz University of Medical Sciences) Mohammad Alizadeh (Tabriz University of Medical Sciences) Razieh Musapour Sultan Abad (Tabriz University of Medical Sciences) Sona Barkabi-Zanjani (Tabriz University of Medical Sciences) Mehran Mesgari-Abbasi (Tabriz University of Medical Sciences)

저널정보: 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.35 No.4

발행연도: 2020.12

수록면: 32 - 39 (8page)

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Ambient air pollution (AAP), as an important environmental health problem, affects everyone. A large body of literature links AAP, such as sulfur dioxide (SO₂) and ozone (O₃), with a wide range of non-communicable diseases. The aim of the present study was to investigate the effects of the pollutants on the bone metabolism biochemical parameters in a rat model. Thirty-two male Wistar rats were divided to four groups: control, SO₂ (10 ppm), O₃ (0.6 ppm), and AAP groups. After 5 weeks of exposure (3 hours/day, 6 days/week), blood samples were taken, and biochemical parameters were assayed. Vitamin D level of the AAP group was higher than the control and SO₂ groups (p=0.004 and 0.003). Parathyroid hormone (PTH) level of the O₃ group was significantly higher than the AAP group (p=0.006). Alkaline phosphatase (ALP), phosphorus, magnesium levels of the SO₂ group; Vit D, ALP, osteocalcin (OC), and PTH of O₃ group; and OC and osteoprotegerin (OPG) of AAP group were higher than those of control group but differences were not significant. Calcium level of the SO₂ group; OPG and calcium of O₃ group; and PTH of AAP group were less than those of control group but differences were not significant (p＞0.05). The results showed significant effect of AAP with natural daylight on vitamin D and also O₃ on PTH of the rats. In the concentrations and conditions of the study, we didn’t find any significant unwanted effects of AAP, SO₂, and O₃ on the bone biochemical parameters. More investigations with more concentrations and exposure time are recommended.

#Air pollution #bone #ozone #rats #sulfur dioxide #Vitamin D

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