지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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ObjectivesZZAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder showing many neuropsychological deficits. Many environmental risk factors have been thought to increase the risk for the disorder. We examined blood iron levels in children with ADHD and a control group to find an association between iron deficit and diagnosis, neuropsychological characteristics and clinical features.
MethodsZZAn ADHD group (n=50) and control group (n=45) of children 6–12 years of age were recruited. Both groups were diagnosed by semi-structured interview, and they were evaluated using the Korean version of the ADHD Rating Scale (K-ARS), Korean version of IOWA Conner’s Rating Scale (K-IOWA), intelligence quotient (IQ), and neurocognitive function tests (continuous performance test, children’s color trails test, Stroop color-word test). Iron levels in blood were determined using the inductively coupled plasma mass spectrometry instrument. Independent t-test and correlation were used to determine the relation of blood iron levels with symptom ratings and neurocognitive function. Logistic regression was performed to determine the diagnostic value of blood iron levels.
ResultsZZBlood iron levels were significantly lower in ADHD than in control and showed negative correlation with K-ARS and K-IOWA scores. Blood iron levels showed positive association with IQ and Stroop color-word test results and negative association with results of continuous performance testing. Low blood iron levels predicted the diagnosis of ADHD.
ConclusionZZLower levels of blood iron were associated with ADHD symptom severity, IQ, and frontal lobe-mediated neurocognitive function. As blood iron levels may influence ADHD, measurement of iron levels in blood may be useful for evaluation of symptoms and neurocognitive function in ADHD.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
American Psychiatric Association / 2013 / Diagnostic and statistical manual of mental disorders (DSM-5®) / American Psychiatric Association
Barkley RA / 1997 / Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD / Psychol Bull 121:65~94
Nigg JT / 2004 / Evaluating the endophenotype model of ADHD neuropsychological deficit: results for parents and siblings of children with ADHD combined and inattentive subtypes / J Abnorm Psychol 113:614~625
Milberger S / 1996 / Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children / Am J Psychiatry 153:1138~1142
Mick E / 2002 / Impact of low birth weight on attention-deficit hyperactivity disorder / J Dev Behav Pediatr 23:16~22
Barkley RA / 1997 / Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD / Psychol Bull 121:65~94
Nigg JT / 2004 / Evaluating the endophenotype model of ADHD neuropsychological deficit: results for parents and siblings of children with ADHD combined and inattentive subtypes / J Abnorm Psychol 113:614~625
Milberger S / 1996 / Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children / Am J Psychiatry 153:1138~1142
Mick E / 2002 / Impact of low birth weight on attention-deficit hyperactivity disorder / J Dev Behav Pediatr 23:16~22
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