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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제14권 제3호
- 발행연도
- 2016.1
- 수록면
- 279 - 285 (7page)
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초록· 키워드
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Objective: We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice.
Methods: MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minutes prior to MK-801 for the final 4 days. Spatial memory performance was measured using a Morris water maze (MWM) test for 9 days (four trials/day). Immunohistochemistry with bromodeoxyuridine (BrdU) was used to identify newborn cells labeled in tissue sections from the dentate gyrus of the hippocampus.
Results: MK-801 administration over 9 days significantly impaired memory performance in the MWM test compared to untreated controls (p＜0.05) and these deficits were blocked by treatment with olanzapine (p＜0.05) but not haloperidol. The administration of MK-801 also resulted in a decrease in the number of BrdU-labeled cells in the dentate gyrus (28.6%; p＜0.01), which was prevented by treatment with olanzapine (p＜0.05) but not haloperidol.
Conclusion: These results suggest that olanzapine has a protective effect against cognitive impairments induced by MK-801 in mice via the stimulating effects of neurogenesis.
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등록된 정보가 없습니다.
참고문헌 (50)
참고문헌 신청
Stahl SM / 2008 / Stahl's essential psychopharmacology / Cambridge University Press :247~253
Citrome L / 2014 / Unmet needs in the treatment of schizophrenia:new targets to help different symptom domains / J Clin Psychiatry 75(Suppl 1):21~26
Yatham LN / 2005 / Atypical antipsychotics in bipolar depression: potential mechanisms of action / J Clin Psychiatry 66(Suppl 5):40~48
Keefe RS / 2007 / Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial / Arch Gen Psychiatry 64:633~647
Meltzer HY / 1995 / Psychopharmacology / Raven Press :1277~1286
Citrome L / 2014 / Unmet needs in the treatment of schizophrenia:new targets to help different symptom domains / J Clin Psychiatry 75(Suppl 1):21~26
Yatham LN / 2005 / Atypical antipsychotics in bipolar depression: potential mechanisms of action / J Clin Psychiatry 66(Suppl 5):40~48
Keefe RS / 2007 / Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial / Arch Gen Psychiatry 64:633~647
Meltzer HY / 1995 / Psychopharmacology / Raven Press :1277~1286
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