지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 447 - 452 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe purpose of this study was to compare duloxetine monotherapy to combination therapy with other antidepressants in patients with major depressive disorder in a clinical, real world setting.
MethodsaaAn eight-week, retrospective, multi-center study of outpatients with major depressive disorder was undertaken. After screening 415 patients, enrolled in this study from July 2009 to June 2014 were 82 patients from among three centers who had been taking duloxetine with or without other antidepressant and not administered with atypical antipsychotics. We compared the mean changes of the Clinical Global Impression-Severity Scale (CGI-S) as a primary measure and the discontinuation rate as a secondary measure between the duloxetine monotherapy group (n=36, 43.9%) and the combination therapy with other antidepressants group (n=46, 56.1%) at baseline, one, two, four and eight weeks.
ResultsaaThere were no significant differences across the demographic characteristics between two groups. There was, however, a statistically greater improvement on the CGI-S at weeks 2, 4 and 8 in the combination group compared with the monotherapy group. There were no significant differences in discontinuation rate and adverse events between two groups. No serious adverse events were reported in both groups during the study period.
ConclusionaaThis result suggests that the duloxetine combination therapy with other antidepressants could improve effectiveness and have comparable tolerability with the monotherapy in the treatment of outpatients with major depressive disorders in a naturalistic setting. Adequately powered, well-controlled clinical trials are strongly warranted to confirm our findings due to methodological shortcomings.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
United States. Depression Guideline Panel / 1993 / Agency for Health Care Policy and Research. Depression in Primary Care
Rush AJ / 2011 / Combining medications to enhance depression outcomes(CO-MED) : acute and long-term outcomes of a single-blind randomized study / Am J Psychiatry 168:689~701
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
American Psychiatric Association / 2000 / Practice guideline for the treatment of patients with major depressive disorder (revision) / Am J Psychiatry 157(4 Suppl):1~45
Thase ME / 2011 / Antidepressant combinations: widely used, but far from empirically validated / Can J Psychiatry 56:317~323
Rush AJ / 2011 / Combining medications to enhance depression outcomes(CO-MED) : acute and long-term outcomes of a single-blind randomized study / Am J Psychiatry 168:689~701
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
American Psychiatric Association / 2000 / Practice guideline for the treatment of patients with major depressive disorder (revision) / Am J Psychiatry 157(4 Suppl):1~45
Thase ME / 2011 / Antidepressant combinations: widely used, but far from empirically validated / Can J Psychiatry 56:317~323
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