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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives ZZThe aim of this study was to examine the drug adherence and treatment effect of the paliperidone long acting injection (LAI) in patients with schizophrenia or other psychotic disorders. MethodsZZWe reviewed the medical charts of patients who were prescribed paliperidone LAI from January 2010 to April 2014. Date of each injection, last observation, and first admission after use of the drug were obtained. Kaplan-Meier survival analysis was used for calculation of drug adherence. The dose of paliperidone LAI, concurrent oral antipsychotics, and anticholinergic agent was also obtained. Antipsychotics dose was calculated as olanzapine equivalent dose. ResultsZZThe drug adherence of the paliperidone LAI on day 365 was 65%. The reasons for all cause discontinuation were follow-up loss, no effect, poor insight, rejection, extrapyramidal symptom, pain, etc. A total dose of 9.1 mg of oral antipsychotics was decreased, while the dose of anticholinergic agent was increased. ConclusionZZThe drug adherence of the paliperidone LAI was 65%, which was concordant with previous studies. The dose of concurrent oral antipsychotics was increased, while the dose of anticholinergic agent was decreased.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Alphs L / 2011 / Onset of efficacy with acute long-acting injectable paliperidone palmitate treatment in markedly to severely ill patients with schizophrenia: post hoc analy
Attard A / 2014 / Paliperidone palmitate long-acting injection--prospective year-long follow-up of use in clinical practice / Acta Psychiatr Scand 130 : 46 ~ 51
Bhanji NH / 2004 / A review of compliance, depot intramuscular antipsychotics and the new long-acting injectable atypical antipsychotic risperidone in schizophrenia / Eur Neu
Citrome L / 2009 / Olanzapine pamoate: a stick in time? A review of the efficacy and safety profile of a new depot formulation of a second-generation antipsychotic / Int J C
Fatemi SH / 2009 / The neurodevelopmental hypothesis of schizophrenia, revisited / Schizophr Bull 35 : 528 ~ 548
Attard A / 2014 / Paliperidone palmitate long-acting injection--prospective year-long follow-up of use in clinical practice / Acta Psychiatr Scand 130 : 46 ~ 51
Bhanji NH / 2004 / A review of compliance, depot intramuscular antipsychotics and the new long-acting injectable atypical antipsychotic risperidone in schizophrenia / Eur Neu
Citrome L / 2009 / Olanzapine pamoate: a stick in time? A review of the efficacy and safety profile of a new depot formulation of a second-generation antipsychotic / Int J C
Fatemi SH / 2009 / The neurodevelopmental hypothesis of schizophrenia, revisited / Schizophr Bull 35 : 528 ~ 548
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