지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 181 - 189 (9page)
이용수
초록· 키워드
오류제보하기
Objectives：Paliperidone palmitate long-acting injection(PP) is an effective and broadly well tolerated treatment in practice. The aim of this study was to determine factors relating to discontinuation with treatment with PP, we analyzed the time course and causes of PP discontinuation that occurred in 12 months period in a clinical setting.
Methods：Retrospective database of 81 patients with schizophrenia were reviewed for analyzing the duration of PP and the reasons for discontinuation(from June 2011 to November 2016), with the motives for discontinuation coded. The causes for termination were analyzed.
Results：Overall, 58% patients discontinued PP beyond 12 months from initiation. The common reasons for discontinuation were follow-up loss(42.5%), no effect(19.1%), side effect(19.1%). extrapyramidal symptom accounted for 44.4% of all side effect inducing discontinuation. Pain, somnolence accounted for 22.2% of side effect, respectively. Inpatient initiation, switched from risperidone, risperidone long-acting injection(LAI), compliance before injection, hospitalization during treatment course, GAF score at last LAI, CGI-S at last LAI were associated with discontinuation on univariate analysis. However, only hospitalization during treatment course was independently associated with discontinuation on multivariate analysis.
Conclusion：Hospitalization after PP was associated with 12-month PP discontinuation. Prospective researches using more objective tools are needed to clarify the reasons for PP discontinuation.
Methods：Retrospective database of 81 patients with schizophrenia were reviewed for analyzing the duration of PP and the reasons for discontinuation(from June 2011 to November 2016), with the motives for discontinuation coded. The causes for termination were analyzed.
Results：Overall, 58% patients discontinued PP beyond 12 months from initiation. The common reasons for discontinuation were follow-up loss(42.5%), no effect(19.1%), side effect(19.1%). extrapyramidal symptom accounted for 44.4% of all side effect inducing discontinuation. Pain, somnolence accounted for 22.2% of side effect, respectively. Inpatient initiation, switched from risperidone, risperidone long-acting injection(LAI), compliance before injection, hospitalization during treatment course, GAF score at last LAI, CGI-S at last LAI were associated with discontinuation on univariate analysis. However, only hospitalization during treatment course was independently associated with discontinuation on multivariate analysis.
Conclusion：Hospitalization after PP was associated with 12-month PP discontinuation. Prospective researches using more objective tools are needed to clarify the reasons for PP discontinuation.
목차
서론
연구 대상 및 방법
결과
고찰
참고문헌
참고문헌 (29)
참고문헌 신청
[단행본] - Gelder M / 2000 / New Oxford Textbook of Psychiatry / Oxford University Press
[학술지(정기간행물)] - Schennach R / 2012 / Predictors of relapse in the year after hospital discharge among patients with schizophrenia / Psychiatr Serv 63 : 87 ~ 90
[학술지(정기간행물)] - Chen EY / 2005 / A prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patients / Schizophr Res 77 : 99 ~ 104
[학술지(정기간행물)] - Pigott TA / 2003 / Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia:a placebo-controlled 26-week study / J Clin Psychiatry 64 : 1048 ~ 1056
[학술지(정기간행물)] - Fatemi SH / 2009 / The neurodevelopmental hypothesis of schizophrenia, revisited / Schizophr Bull 35 : 528 ~ 548
[학술지(정기간행물)] - Schennach R / 2012 / Predictors of relapse in the year after hospital discharge among patients with schizophrenia / Psychiatr Serv 63 : 87 ~ 90
[학술지(정기간행물)] - Chen EY / 2005 / A prospective 3-year longitudinal study of cognitive predictors of relapse in first-episode schizophrenic patients / Schizophr Res 77 : 99 ~ 104
[학술지(정기간행물)] - Pigott TA / 2003 / Aripiprazole for the prevention of relapse in stabilized patients with chronic schizophrenia:a placebo-controlled 26-week study / J Clin Psychiatry 64 : 1048 ~ 1056
[학술지(정기간행물)] - Fatemi SH / 2009 / The neurodevelopmental hypothesis of schizophrenia, revisited / Schizophr Bull 35 : 528 ~ 548
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UCI(KEPA) : I410-ECN-0101-2018-512-001471094