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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 698 - 702 (5page)
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초록· 키워드
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Previous studies reported some relationships between donepezil treatment and hippocampus in Alzheimer’s disease (AD). However, due to methodological limitations, their close relationships remain unclear. The aim of this study is to predict treatment response to donepezil by utilizing the automated segmentation of hippocampal subfields volumes (ASHS) in AD. Sixty four AD patients were prescribed with donepezil and were followed up for 24 weeks. Cognitive function was measured to assess whether there was a response from the donepezil treatment. ASHS was implemented on non-responder (NR) and responder (TR) groups, and receiver operator characteristic (ROC) analysis was conducted to evaluate the sensitivity, specificity, and accuracy of hippocampal subfields in predicting response to donepezil. The left total hippocampus and the CA1 area of the NR were significantly smaller than those of the TR group. The ROC curve analysis showed the left CA1 volumes showed highest area under curve (AUC) of 0.85 with a sensitivity of 88.0%, a specificity of 74.0% in predicting treatment response to donepezil treatment. We expect that hippocampal subfields volume measurements that predict treatment responses to current AD drugs will enable more evidence-based, individualized prescription of medications that will lead to more favorable treatment outcomes.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Wallin AK / 2009 / Can CSF biomarkers or pre‐treatment progression rate predict response to cholinesterase inhibitor treatment in Alzheimer’s disease? / Int J Geriatr Psychiatry 24:638~647
Shinoe T / 2005 / Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus / J Neurosci 25:11194~11200
Martin S / 2007 / The rodent hippocampus and spatial memory : from synapses to systems / Cell Mol Life Sci 64:401~431
Daugherty AM / 2016 / Age differences in hippocampal subfield volumes from childhood to late adulthood / Hippocampus 26:220~228
de Flores R / 2015 / Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease / Neuroscience 309:29~50
Shinoe T / 2005 / Modulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus / J Neurosci 25:11194~11200
Martin S / 2007 / The rodent hippocampus and spatial memory : from synapses to systems / Cell Mol Life Sci 64:401~431
Daugherty AM / 2016 / Age differences in hippocampal subfield volumes from childhood to late adulthood / Hippocampus 26:220~228
de Flores R / 2015 / Structural imaging of hippocampal subfields in healthy aging and Alzheimer’s disease / Neuroscience 309:29~50
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