지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In the present study, we determined the effect of $18{\beta}$-glycyrrhetinic acid ($18{\beta}$-GA) in the mice model bearing xenografts of HT-29 human colon cancer cell line. Data from the cytotoxicity assay displayed that $18{\beta}$-GA induced cell death in HT-29. The cytotoxicity was enhanced as the $18{\beta}$-GA treatment was prolonged. In case of 72 hrs treatment, $LD_{50}$ of $18{\beta}$-GA was approximately $90{\mu}M$, and the efficacy at $100{\mu}M$ of $18{\beta}$-GA appeared to be equivalent to that of doxorubicin at $1{\mu}M$. Based on the in vitro data, we tested the anti-tumor effect of $18{\beta}$-GA in thymic mice (Balb/c strain). Xenograft tumors were generated by subcutaneous injection of HT-29 ($3{\times}10^6cells/mouse$) to mice and the mice were treated intraperitoneally with $18{\beta}$-GA ($50{\mu}g/time/mouse$) every other day for 4 times. The tumor volumes were measured for a period of 14 days. Data displayed that the $18{\beta}$-GA treatment reduced the tumor volumes (P < 0.05) as compared to control mice. However, this activity was demolished when athymic mice (Balb/c nu/nu) were used instead of thymic mice. This observation appeared that T lymphocyte played an important role in the anti-tumor activity. In conclusion, our results indicate that $18{\beta}$-GA has anti-tumor activity in HT-29 tumor-bearing mice, which may be associated with T cells.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Streptococcus mutans 균에 의해 형성된 바이오필름에 대한 Glycyrrhetinic acid의 불안정화 효과
대한구강보건학회지
2016 .03
-
Mouse tumor model and overview of surgical tumor model
한국실험동물학회 학술발표대회 논문집
2020 .02
-
A computerized method for measuring xenograft tumor volume enhances the accuracy and consistency of tumor size assessment in xenograft cancer models
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Retrospective analysis of tumor xenograft models for human cancer therapeutics
한국실험동물학회 학술발표대회 논문집
2015 .02
-
18b-glycyrrhetinic acid의 S. mutans의 바이오필름 형성에 대한 억제효과
대한구강보건학회지
2018 .03
-
Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma
Cancer Research and Treatment
2018 .01
-
Efficient Anti-Tumor Immunotherapy Using Tumor Epitope-Coated Biodegradable Nanoparticles Combined With Polyinosinic-Polycytidylic Acid and an Anti-PD1 Monoclonal Antibody
Immune Network
2022 .10
-
Murine Mammary Carcinoma Induces Chronic Systemic Inflammation and Immunosuppression in BALB/c Mice
Journal of Breast Cancer
2022 .06
-
Pectolinarigenin suppresses the tumor growth in gastric cancer
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Established tumor model in nude mice using canine tumor cells, ChMP
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Mouse models in cancer research
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Evaluation of low dose administration of N-methyl-N-nitrosourea to p53 heterozygous knockout mouse
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Tumor Growth Suppression and Enhanced Radioresponse by an Exogenous Epidermal Growth Factor in Mouse Xenograft Models with A431 Cells
Cancer Research and Treatment
2015 .01
-
Inducible Mouse Models for Cancer Drug Target Validation
대한암예방학회지
2016 .01
-
Evaluation of urethane-induced lung tumor in p53 heterozygous null mice for a short-term carcinogenicity study
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Suboptimal control status of young hypertensive population
Clinical Hypertension
2023 .01
-
Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse
Gut and Liver
2015 .01
-
Multifocality and Bilaterality of Papillary Thyroid Microcarcinoma
Clinical and Experimental Otorhinolaryngology
2015 .01
-
Effects of canine mesenchymal stem cells-derived exosomes in a mouse model of canine mammary tumor
예방수의학회지
2020 .01
-
Mouse models for cancer research
한국실험동물학회 학술발표대회 논문집
2020 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0