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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2003.1
- 수록면
- 472 - 477 (6page)
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초록· 키워드
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Purpose: The potential therapeutic application of the
tumor necrosis factor-related apoptosis-inducing ligand
(TRAIL), in the treatment of multiple myeloma (MM), was
recently proposed. However, there have been some
problems with the use of TRAIL, due to the appearance
of TRAIL-resistant cells in MM. The effect of arsenic
trioxide (As2O3) on the rate of apoptosis induced by
TRAIL was evaluated in MM cells.
Materials and Methods: Using TRAIL-sensitive (RPMI-
8226) and TRAIL-resistant (ARH-77 and IM-9) MM cell
lines, the cell viability, induction of apoptosis, and change
in the caspases were examined after treatment with
TRAIL alone, or in combination with various concentrations
of As2O3.
Results: Incubating the cell lines with As2O3 augmented
the TRAIL-induced apoptosis in the MM cell lines,
according to the As2O3 concentration. Apoptosis was
mediated through caspase activation. When TRAIL was
used alone, caspase8 was activated in the RPMI-8226 cell
lines, but not in the ARH-77 and IM-9 cell lines. When
As2O3 was added to TRAIL, caspase-9 was activated in
the ARH-77 and IM-9 cells.
Conclusion: The use of As2O3, in combination with
TRAIL, would help enhance the level of TRAIL-induced
apoptosis, and overcome the TRAIL-resistance, in MM
cells. (Cancer Res Treat. 2003;35:472-477)
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