지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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The Fgf signaling pathway plays an important role in the sequential process of tooth development and morphogenesis. Ets (E-twenty-six) is a family of transcription factors regulated by the Fgf signaling pathway and is involved in the development of various organs. Although most Ets proteins act as transcriptional activators, Etv5 (Ets version 5) and Etv6 (Ets version 6) reportedly act as transcriptional repressors. Expression of Etv5 mRNA has been reported in developing teeth, whereas Etv6 expression has not been reported yet. In this study, we examined the expression pattern of Etv6 in tooth development and compared the expression patterns of Etv5 and Etv6. Etv5 was strongly expressed in epithelium, except in the enamel knot, while Etv6 was strongly expressed in dental lamina and stellate reticulum. Although their expression patterns overlapped in the stellate reticulum, there were many differences overall. This result suggests that Etv5 and Etv6 regulate different genes.
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참고문헌 (22)
참고문헌 신청
Thesleff I / 1995 / Regulation of organogenesis. Common molecular mechanisms regulating the development of teeth and other organs / Int J Dev Biol 39:35~50
Seppo Vainio / 1993 / Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development / Cell 75(1):45~58
Bei M / 1998 / FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development / Development 125:4325~4333
Hardcastle Z / 1998 / The Shh signaling pathway in tooth development : defects in Gli2 and Gli3 mutants / Development 125:2803~2811
A.S. Tucker / 2016 / Molecular Genetics of Tooth Morphogenesis and Patterning: The Right Shape in the Right Place / Journal of Dental Research 78(4):826~834
Seppo Vainio / 1993 / Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development / Cell 75(1):45~58
Bei M / 1998 / FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development / Development 125:4325~4333
Hardcastle Z / 1998 / The Shh signaling pathway in tooth development : defects in Gli2 and Gli3 mutants / Development 125:2803~2811
A.S. Tucker / 2016 / Molecular Genetics of Tooth Morphogenesis and Patterning: The Right Shape in the Right Place / Journal of Dental Research 78(4):826~834
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