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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2002.1
- 수록면
- 426 - 431 (6page)
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초록· 키워드
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Purpose: The role of P38 mitogen-activated protein
kinase (MAPK) in gastric cancer invasion has not yet
been determined. In this study, we examined the effects
of SB203580, a specific P38 MAPK inhibitor, on the in
vitro invasion of gastric cancer and upon the molecules
involved in this process.
Materials and Methods: Human gastric cancer SNU-638
cells were maintained in RPMI 1640 supplemented with
10% FBS. BIOCOAT matrigel invasion chambers were
used to examine in vitro invasiveness, zymography for
gelatinase activity, CAT assay for uPA promoter activity
and Western and Northern blotting to determine protein
and mRNA levels, respectively.
Results: Treatment of SNU-638 cells with SB203580, a
specific P38 MAPK inhibitor, reduced in vitro invasiveness,
dose-dependently. SB203580 treatment was found
to decrease both mRNA expression and uPA promoter
activity in gastric SNU-638 cells. In vitro invasion of
SNU-638 cells was partially abrogated by uPA-neutralizing
antibodies. The activities of MMPs were not significantly
altered by SB203580.
Conclusion: Our results suggest that P38 MAPK is a
potential therapeutic target for inhibiting uPA-dependent
gastric tumor invasiveness and metastasis. (Cancer Res Treat. 2002;34:426-431)
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