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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 159 - 167 (9page)
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Purpose: We wanted to demonstrate the anti-cancer effect and interaction between belotecan and cisplatin on gastric cancer cell line and we evaluated the mechanisms of this synergistic effect in vitro.
Materials and Methods: The growth inhibitory effect of belotocan and cisplatin against several gastric cancer cell lines (SNU-5, SNU-16 and SNU-601) was estimated by tetrazolium dye assay. The effect of a combination treatment was evaluated by the isobologram method. The biochemical mechanisms for the interaction between the drugs were analyzed by measuring the formation of DNA interstrand cross-links (ICLs) and DNA topo-I activity.
Results: Belotecan showed synergism with cisplatin for growth inhibitory effect on the gastric cancer cell lines SNU-5, and SNU-16, but this was subadditive on the SNU- 601 cell line. The formation of DNA ICLs in SNU-16 cells by cisplatin was increased by combination with belotecan, but this was not affected in SNU-601 cells. The topo-I inhibition by belotecan was enhanced at high concentrations of cisplatin in SNU-16, but not in SNU-601 cells.
Conclusion: Belotecan and cisplatin show various combination effect against gastric cancer cells. The synergism between cisplatin and belotecan could be the result of one of the following mechanisms: the modulating effect of belotecan on the repair of cisplatin-induced DNA adducts and the enhancing effect of cisplatin on the belotecan-induced topo-I inhibitory effect. (Cancer Res Treat. 2006;38:159-167)
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참고문헌 (25)
참고문헌 신청
/ 1981;78 / two forms of type I DNA topoisomerase from HeLa cell nuclei : 3487 ~ 91
/ 1985;24 / Adducts of the antitumor drug cis- diamminedichloroplatinum(II) with DNA : 707 ~ 13
/ 1988;27 / Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum : 4730 ~ 4
/ 1989;49 / Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I evidence for a specific receptor site and a relaxation to antitu
/ 1990;50 / Decreased accumulation as a mechanism of resistance to cis-diamminedichloroplatinum relation to DNA damage and repair : 2549 ~ 53
/ 1985;24 / Adducts of the antitumor drug cis- diamminedichloroplatinum(II) with DNA : 707 ~ 13
/ 1988;27 / Enhanced DNA repair as a mechanism of resistance to cis-diamminedichloroplatinum : 4730 ~ 4
/ 1989;49 / Structure-activity study of the actions of camptothecin derivatives on mammalian topoisomerase I evidence for a specific receptor site and a relaxation to antitu
/ 1990;50 / Decreased accumulation as a mechanism of resistance to cis-diamminedichloroplatinum relation to DNA damage and repair : 2549 ~ 53
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