지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 197 - 201 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Smad proteins mediate cellular signaling
through the transforming growth factor-β family (TGF-β
s). Smads 2 and 3 transmit signals from TGF-β, and
Smad4 is a common mediator, as well. However, little is
known concerning the expression patterns of Smads in
lymphoid tissue.
Materials and Methods: Immunohistochemistry for
Smad3 and Smad4 was performed on paraffin-embedded
tissue sections collected from 26 T- or NK-cell
lymphomas.
Results: Nearly all cells in germinal centers were positive
for Smad3, and more than 50% of paracortical cells
were positive for Smad3 in reactive lymphoid tissue.
When Smad4 immunostaining was conducted, nearly all
the cells in the germinal centers showed diffuse cytoplasmic
staining, and most of them exhibited nuclear positivity,
as well. In addition, more than 50% of the cells in
the paracortex were positive for Smad4. Furthermore, the Smad3 staining pattern was preserved in all malignant
lymphomas, but four of these cases (15%) exhibited decreased
expression of Smad4. All lymphoblastic lymphomas
showed strong positivity in most of tumor cells, but
one unspecified peripheral lymphoma, two nasal NK/T
cell lymphomas, and one anaplastic large cell lymphoma
were negative for Smad4.
Conclusions: These results suggest that TGF-β-specific
Smads may be actively involved in signal transduction
in lymphoid organs and that Smad-mediated TGF-β signaling
pathways are operative in malignant lymphoma. In
addition, loss of Smad4 expression might be associated
with development of some T-cell lymphomas.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Chi SG / 2003 / Oncogenes by TGF-β1 / Cancer Res Treat 35 : 12 ~
Djaborkhel R. / 2000 / Cyclin A down-regulation in TGFbeta1-arrested follicularlymphoma cells / Exp Cell Res 261 : 250 ~ 9
Flanders KC / 2001 / Immunohistochemicalexpression of Smads 1-6 in the 15-day gestation mouseembryo: signaling by BMPs and TGF-betas / Dev Dyn 220 : 141 ~ 54
Go JH / 2002 / Decreased expression of TGF-β type 2 receptor inprimary B-cell lymphomas of the stomach / Pathol Res Pract 198 : 333 ~ 7
Gorelik L. / 2007 / Transforming growth factor-beta inT-cell biology. Nat Rev Immunol. 2002;2:46-53.12. Rubtsov YP, Rudensky AY. TGFbeta signalling in control ofT-cell-media
Djaborkhel R. / 2000 / Cyclin A down-regulation in TGFbeta1-arrested follicularlymphoma cells / Exp Cell Res 261 : 250 ~ 9
Flanders KC / 2001 / Immunohistochemicalexpression of Smads 1-6 in the 15-day gestation mouseembryo: signaling by BMPs and TGF-betas / Dev Dyn 220 : 141 ~ 54
Go JH / 2002 / Decreased expression of TGF-β type 2 receptor inprimary B-cell lymphomas of the stomach / Pathol Res Pract 198 : 333 ~ 7
Gorelik L. / 2007 / Transforming growth factor-beta inT-cell biology. Nat Rev Immunol. 2002;2:46-53.12. Rubtsov YP, Rudensky AY. TGFbeta signalling in control ofT-cell-media
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
B형 미만성 대세포 림프종에서 Smad 단백의 발현
Journal of Pathology and Translational Medicine
2004 .01
-
Clinicopathological Significance of SMAD4 Expression in Breast Cancer
Journal of Breast Disease
2019 .01
-
Smad1 Expression in Follicular Lymphoma
Journal of Pathology and Translational Medicine
2015 .01
-
인체위암조직에서 Smad4 및 Smad7 단백질 발현의 예후 인자로서의 의의
대한외과학회 학술대회 초록집
2002 .10
-
위선암종에서 Smad4의 발현
Journal of Pathology and Translational Medicine
2003 .01
-
Smad4 Expression in Hepatocellular Carcinoma Differs by Hepatitis Status
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Clinicopathological Characterization and Prognostic Implication of SMAD4 Expression in Colorectal Carcinoma
Journal of Pathology and Translational Medicine
2019 .01
-
Expression of Smad7 in Cholangiocarcinoma: Prognostic Significance and Implications for Tumor Metastasis
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Bone Morphogenetic Protein 2-induced MAPKs Activation Is Independent of the Smad1/5 Activation
International Journal of Oral Biology
2009 .01
-
Dendritic cell specific targeting of Smad2 enhances anti-tumor immunity
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Signaling web of SMADs and STAT3 in the development of arthritogenic Th17
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Ellagic Acid Exerts Anti-proliferation Effects via Modulation of Tgf-Β/Smad3 Signaling in MCF-7 Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
음양곽(淫羊藿) 열수 추출물의 Smad 신호 억제를 통한 간성상세포의 활성 조절
대한한의학방제학회지
2018 .01
-
Expression of Minichromosome Maintenance Protein 7 and Smad 4 in Squamous Cell Carcinoma of the Esophagus
Journal of Pathology and Translational Medicine
2010 .01
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2017 .08
-
Copper oxide nanoparticles induce a fibrotic response via TGF-β1/Smad3 signaling in human airway epithelial cells
한국실험동물학회 학술발표대회 논문집
2018 .01
-
The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
Journal of Pathology and Translational Medicine
2018 .01
-
The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
Tuberculosis and Respiratory Diseases
2019 .01
-
Association between SMAD2 Gene and Serum Liver Enzyme Levels in the Korean Population
대한의생명과학회지
2013 .06
-
The role of smad7 on epidermal growth factor (EGF) signaling pathway
대한외과학회 학술대회 초록집
2009 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0