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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 583 - 595 (13page)
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초록· 키워드
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Purpose This study analyzed the outcomes of patients with resected extrahepatic bile duct cancer (EHBDC) in order to clarify the role of adjuvant treatments in these patients.
Materials and Methods A total of 336 patients with EHBDC who underwent curative resection between 2001 and 2010 were analyzed retrospectively. The treatment types were as follows: surgery alone (n=168), surgery with chemotherapy (CTx, n=90), surgery with radiotherapy (RT) alone (n=29), and surgery with chemoradiotherapy (CRT, n=49).
Results The median follow-up period was 63 months. The 5-year rates of locoregional failure-free survival (LRFFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) for all patients were 56.5%, 59.7%, 36.6%, and 42.0%, respectively.
In multivariate analysis, surgery with RT and CRT was a significant prognostic factor for LRFFS, and surgery with CTx was a significant prognostic factor for DMFS, and surgery with CTx, RT, and CRT was a significant prognostic factor for PFS (p < 0.05). Surgery with CTx and CRT showed association with superior OS (p < 0.05), and surgery with RT had marginal significance (p=0.078). In multivariate analysis of the R1 resection patients, surgery with CRT showed significant association with OS (p < 0.05).
Conclusion Adjuvant RT and CTx may be helpful in improving clinical outcomes of patients with resected EHBDC who have a high risk of disease recurrence, particularly R1 resection patients. Conduct of additional prospective, larger-scale studies will be required in order to confirm the benefit of adjuvant RT and CTx in these patients.
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참고문헌 (19)
참고문헌 신청
Khan SA / 2005 / Cholangiocarcinoma / Lancet 366:1303~1314
Murakami Y / 2013 / Perineural invasion in extrahepatic cholangiocarcinoma : prognostic impact and treatment strategies / J Gastrointest Surg 17:1429~1439
Gwak HK / 2010 / Extrahepatic bile duct cancers : surgery alone versus surgery plus postoperative radiation therapy / Int J Radiat Oncol Biol Phys 78:194~198
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Todoroki T / 2000 / Benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma / Int J Radiat Oncol Biol Phys 46:581~587
Murakami Y / 2013 / Perineural invasion in extrahepatic cholangiocarcinoma : prognostic impact and treatment strategies / J Gastrointest Surg 17:1429~1439
Gwak HK / 2010 / Extrahepatic bile duct cancers : surgery alone versus surgery plus postoperative radiation therapy / Int J Radiat Oncol Biol Phys 78:194~198
정규원 / 2013 / Cancer Statistics in Korea: Incidence, Mortality, Survival and Prevalence in 2010 / Cancer Research and Treatment 45(1):1~14
Todoroki T / 2000 / Benefits of adjuvant radiotherapy after radical resection of locally advanced main hepatic duct carcinoma / Int J Radiat Oncol Biol Phys 46:581~587
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