지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 486 - 490 (5page)
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초록· 키워드
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Background and Objectives Oropharyngeal cancers (OPCs) can be staged down to a lowerstage with p16 positivity and de-escalated therapy has been the common practice. The aim ofthis study is to evaluate the survival outcomes based on various clinical factors in advancedOPC patients. Subjects and Method A total of 58 OPC patients in the stage IVA based on the AmericanJoint Committee on Cancer 7th edition were treated with primary surgery or primary chemoradiationtherapy from 2010 to 2016. A survival analysis was carried out using the Kaplan-Meier method, log-rank test, and Cox proportional hazards model. Results The median follow-up was 39.5 months. Thirty-eight and 20 patients received surgery-based and radiation therapy (RT)-based treatments, respectively. Clinical T-stage and treatmentmethod were significant risk factors for 5-year disease-free survival (DFS) rate, and thetreatment method was the only significant risk factor for overall-survival (OS) rate. 5-year DFSrate in the surgery-based treatment and RT-based treatment was 76.1% and 36.0% (p=0.001). On multivariate analysis, the surgery-based treatment group was associated with a significantlyreduced hazard of death [the hazard ratio (HR) for the radiation-based treatment was 6.565compared to the surgery-based treatment, p=0.002]. 5-year OS rate in the surgery-based treatmentand RT-based treatment was 91.1% and 53.4% (p=0.003), respectively. On the multivariateanalysis, the surgery-based treatment group was associated with a significantly reducedhazard of death (the HR for the radiation-based treatment was 7.544 compared to the surgerybasedtreatment, p=0.012). Conclusion The primary surgery-based treatment for advanced OPC showed a better survivaloutcome than the primary radiation-based treatment, irrespective of p16 positivity.
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참고문헌 (9)
참고문헌 신청
Siegel RL / 2016 / Cancer statistics, 2016 / CA Cancer J Clin 66(1):7~30
Pytynia KB / 2014 / Epidemiology of HPVassociated oropharyngeal cancer / Oral Oncol 50(5):380~386
Pfister DG / 2020 / Head and neck cancers, version 2.2020, NCCN Clinical Practice Guidelines in oncology / J Natl Compr Canc Netw 18(7):873~898
Parsons JT / 2002 / Squamous cell carcinoma of the oropharynx:Surgery, radiation therapy, or both / Cancer 94(11):2967~2980
Allal AS / 2003 / Quality of life in patients with oropharynx carcinomas : Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy / Head Neck 25(10):833~839
Pytynia KB / 2014 / Epidemiology of HPVassociated oropharyngeal cancer / Oral Oncol 50(5):380~386
Pfister DG / 2020 / Head and neck cancers, version 2.2020, NCCN Clinical Practice Guidelines in oncology / J Natl Compr Canc Netw 18(7):873~898
Parsons JT / 2002 / Squamous cell carcinoma of the oropharynx:Surgery, radiation therapy, or both / Cancer 94(11):2967~2980
Allal AS / 2003 / Quality of life in patients with oropharynx carcinomas : Assessment after accelerated radiotherapy with or without chemotherapy versus radical surgery and postoperative radiotherapy / Head Neck 25(10):833~839
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