Neuropsychological Outcome One Year after Carotid Revascularization: A before-and-after Study

Laura Casas-Hernanz; Maite Garolera; Dolors Badenes; Salvador Quintana; Susana Millán; Noemi Calzado; Jorge de Francisco; Josep Royo; Miquel Aguilar

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자료유형: 학술저널

저자정보: Laura Casas-Hernanz (Hospital Universitari Mútua Terrassa) Maite Garolera (Hospital of Terrassa-Consorci Sanitari de Terrassa) Dolors Badenes (Hospital Universitari Mútua Terrassa) Salvador Quintana (Hospital Universitari Mútua Terrassa) Susana Millán (Unitat d’Urgències) Noemi Calzado (Hospital Universitari Mútua Terrassa) Jorge de Francisco (Hospital Universitari Mútua Terrassa) Josep Royo (Hospital Universitari Mútua Terrassa) Miquel Aguilar (Hospital Universitari Mútua Terrassa)

저널정보: 대한혈관외과학회 Vascular Specialist International Vascular Specialist International Vol.33 No.4

발행연도: 2017.1

수록면: 146 - 155 (10page)

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Purpose: The aim of our study was to determine the clinical profile of patients considered cognitive ‘responders’ to surgery in order to establish clinical variables associated with a favorable cognitive performance. Materials and Methods: A total of 70 patients were included in the study. A wellvalidated, comprehensive standardized neurocognitive battery of tests of about 2 hours was administered. Patients were examined twice, 1-week before surgery and 1-year postoperatively. The criterion to be included in the ‘responder’ group was the following: to obtain a positive difference between post-revascularization and pre-revascularization neuropsychological assessment ≥1 standard deviation in ≥2 tests. Results: Twenty-seven patients (38.6%) were cognitive responders to treatment. In bivariate analysis between responders and non-responders, presence of atrophy (P=0.003), small vessels (P=0.577), symptoms (P=0.046), and age (P=0.030) were the factors statistically significant. When comparing cognitive performance before and after carotid revascularization, significant differences were observed in semantic fluency with a lower performance after 12 months (P=0.004, d=0.29), and in the Language index (Repeatable Battery for the Assessment of Neuropsychological Status) (P=0.005, d=0.34). Conclusion: Patients without neurological symptoms, of a younger age and without atrophy and white matter small vessel lesions are better cognitive responders 1-year after carotid revascularization.

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참고문헌 신청

Mukherjee D / 2011 / Epidemiology and the global burden of stroke / World Neurosurg 76(6 Suppl):S85~S90

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