한국인의 흡연과 사망 위험에 관한 코호트 연구

이은하; 박수경; 고광필; 조인성; 장성훈; 신해림; 강대희; 유근영

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자료유형: 학술저널

저자정보: 이은하 박수경 고광필 조인성 장성훈 신해림 강대희 유근영

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제43권 제2호

발행연도: 2010.1

수록면: 151 - 158 (8page)

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Objectives: The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults. Methods: A total of 14 161 subjects of the Korean Multi-center Cancer Cohort who were over 40 years of age and who were cancer-free at baseline enrollment reported their lifestyle factors, including the smoking status. The median follow-up time was 6.6 years. During the follow-up period from 1993 to 2005, we identified 1159 cases of mortality, including 260 cancer mortality cases with a total of 91 987 person-years, by the national death certificate. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cigarette smoking for total mortality, cancer mortality and disease-specific mortality, as adjusted for age, gender, the geographic area and year of enrollment, the alcohol consumption status, the education level and the body mass index (BMI). Results: Cigarette smoking was significantly associated with an increased risk of total mortality, all-cancer mortality and lung cancer mortality (p-trend, < 0.01, <0.01, <0.01, respectively). Compared to non-smoking, current smokers were at a higher risk for mortality [HR (95% CI)=1.3 (1.1 - 1.5) for total mortality; HR (95% CI)=1.6 (1.1 -2.2) for all-cancer mortality; HR (95%CI)=3.9 (1.9-7.7) for lung cancer mortality]. Conclusions: This study’s results suggest that cigarette smoking might be associated with total mortality, all-cancer mortality and especially lung cancer mortality among Korean adults.

#Cigarette smoking #Cohort studies #Mortality

참고문헌 (23)

참고문헌 신청

Akiba S / 1990 / Cigarette smoking and cancer mortality risk in Japanese men and women--results from reanalysis of the six-prefecture cohort study data / Environ Health Pers

Doll R / 2004 / Mortality in relation to smoking: 50 years’ observations on male British doctors / BMJ 328 (7455) : 1519 ~

Doll R / 2005 / Mortality from cancer in relation to smoking: 50 years observations on British doctors / Br J Cancer 92 (3) : 426 ~ 429

Ezzati M / 2003 / Estimates of global mortality attributable to smoking in 2000 / Lancet 362 (9387) : 847 ~ 852

Godtfredsen NS / 2008 / COPD related morbidity and mortality after smoking cessation: Status of the evidence / Eur Respir J 32 (4) : 844 ~ 853

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