지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: The main purpose of this study was to quantify the risk of mortality linked to various regimens of hypertonic peritoneal dialysis (PD) solution. Methods: A retrospective cohort study of patients using home-based PD was carried out. The prescribed regimen of glucose-based PD solution for all patients, determined on the basis of their individual conditions, was extracted from their medical chart records. The primary outcome was death. The treatment regimens were categorized into 3 groups according to the type of PD solution used: original PD (1.5% glucose), shuffle PD (1.5 and 2.5% glucose), and serialized PD (2.5 and 4.5% glucose). Multivariate analysis (using the Weibull model) was applied to comprehensively examine survival probabilities related to the explanatory variable, while adjusting for other potential confounders. Results: Of 300 consecutive patients, 38% died over a median follow-up time of 30 months (interquartile range: 15-46 months). Multivariate analysis showed that a treatment regimen with continued higher-strength PD solution (serialized PD) resulted in a lower survival rate than when the conventional strength solution was used (adjusted hazard ratio, 2.6; 95% confidence interval, 1.6 to 4.6, p<0.01). Five interrelated risk factors (age, length of time on PD, hemoglobin levels, albumin levels, and oliguria) were significant predictors contributing to the outcome. Conclusions: Frequent exposure to high levels of glucose PD solution significantly contributed to a 2-fold higher rate of death, especially when hypertonic glucose was prescribed continuously.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Kendrick J / 2010 / Strategies for improving long-term survival in peritoneal dialysis patients / Clin J Am Soc Nephrol 5(6):1123~1131
Mateijsen MA / 1999 / Vascular and interstitial changes in the peritoneum of CAPD patients with peritoneal sclerosis / Perit Dial Int 19(6):517~525
Teixeira JP / 2015 / Peritoneal dialysis: update on patient survival / Clin Nephrol 83(1):1~10
Al-Hwiesh AK / 2016 / Changes in peritoneal membrane with different peritoneal dialysis solutions: is there a difference? / Hong Kong J Nephrol 19:7~18
Wen Y / 2015 / High glucose concentrations in peritoneal dialysate are associated with all-cause and cardiovascular disease mortality in continuous ambulatory peritoneal dialysis patients / Perit Dial Int 35(1):70~77
Mateijsen MA / 1999 / Vascular and interstitial changes in the peritoneum of CAPD patients with peritoneal sclerosis / Perit Dial Int 19(6):517~525
Teixeira JP / 2015 / Peritoneal dialysis: update on patient survival / Clin Nephrol 83(1):1~10
Al-Hwiesh AK / 2016 / Changes in peritoneal membrane with different peritoneal dialysis solutions: is there a difference? / Hong Kong J Nephrol 19:7~18
Wen Y / 2015 / High glucose concentrations in peritoneal dialysate are associated with all-cause and cardiovascular disease mortality in continuous ambulatory peritoneal dialysis patients / Perit Dial Int 35(1):70~77
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