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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
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Objective: Impaired local cellular immunity contributes to persistent human papillomavirus (HPV) infection and development of cervical intraepithelial neoplasia (CIN). Programmed death-1 (PD-1) and its ligands PD-ligand-1 (L1) and PD-L2 are negative regulators of T cell activity in various cancers, but few studies exist. The aim of this study was to determine the clinicopathologic and immunologic parameters (PD-1, PD-L1, and PD-L2) related to the persistence/recurrence of CIN after conization. Methods: Medical records of 652 patients diagnosed with CIN and underwent conization were reviewed. The associations between clinicopathologic parameters (e.g., age, parity, initial HPV load, etc.) and persistence/recurrence of CIN were analyzed. Expression of PD-1, PD-L1, and PD-L2 was assessed on 100 conization specimens by immunohistochemistry (IHC) in women matched for propensity-score (50 with persistence/recurrence and 50 without). Results: Initial HPV load (>1,000 relative light unit) and positive margin were shown to be significantly associated with CIN persistence/recurrence (p=0.012 and p<0.001, respectively). Multivariate analysis showed that margin status was an independent predictor of persistence/recurrence (hazard ratio=8.86; 95% confidence interval=1.67–16.81; p<0.001). On IHC analysis, none of the patients expressed PD-L1. PD-1+ T cells were observed in 25 of 100 patients. Also, PD-1+ T cells were significantly correlated with increasing grade of CIN (p=0.031). In addition, patients with persistence/recurrence had increased expression of PD-1 compared with those without (36% vs. 14%, respectively; p=0.020). Although PD-L2 expression did not differ between 2 groups, it was significantly higher in patients with high-grade CIN compared to low-grade (34.7% vs. 12%, respectively; p=0.041). Conclusion: Positive surgical margin and expression of PD-1+ T cells were associated with CIN persistence/recurrence after conization.
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참고문헌 (48)
참고문헌 신청
Insinga RP / 2011 / Incident cervical HPV infections in young women: transition probabilities for CIN and infection clearance / Cancer Epidemiol Biomarkers Prev 20:287~296
Kucera E / 2001 / Is high-risk human papillomavirus infection associated with cervical intraepithelial neoplasia eliminated after conization by large-loop excision of the transformation zone? / Eur J Obstet Gynecol Reprod Biol 100:72~76
Soutter WP / 2006 / Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia / Int J Cancer 118:2048~2055
Melnikow J / 2009 / Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study / J Natl Cancer Inst 101:721~728
Paraskevaidis E / 2004 / The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature / Cancer Treat Rev 30:205~211
Kucera E / 2001 / Is high-risk human papillomavirus infection associated with cervical intraepithelial neoplasia eliminated after conization by large-loop excision of the transformation zone? / Eur J Obstet Gynecol Reprod Biol 100:72~76
Soutter WP / 2006 / Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia / Int J Cancer 118:2048~2055
Melnikow J / 2009 / Cervical intraepithelial neoplasia outcomes after treatment: long-term follow-up from the British Columbia Cohort Study / J Natl Cancer Inst 101:721~728
Paraskevaidis E / 2004 / The role of HPV DNA testing in the follow-up period after treatment for CIN: a systematic review of the literature / Cancer Treat Rev 30:205~211
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