Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease

전다혜; 염형선; 양재원; 송종석; 이형근; 김현창

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자료유형: 학술저널

저자정보: 전다혜 염형선 양재원 송종석 이형근 김현창

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제50권 제6호

발행연도: 2017.1

수록면: 369 - 376 (8page)

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Objectives: Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI). Methods: The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI. Results: Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations. Conclusions: The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.on

#Dry eye syndromes #Keratoconjunctivitis sicca #Vitamin D #25-Hydroxyvitamin D2 #Korea

참고문헌 (26)

참고문헌 신청

Ahn JM / 2014 / Prevalence of and risk factors associated with dry eye: the Korea National Health and Nutrition Examination Survey 2010-2011 / Am J Ophthalmol 158 (6) : 1205

Chiu KC / 2004 / Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction / Am J Clin Nutr 79 (5) : 820 ~ 825

Elizondo RA / 2014 / Effect of vitamin D receptor knockout on cornea epithelium wound healing and tight junctions / Invest Ophthalmol Vis Sci 55 (8) : 5245 ~ 5251

Etemadifar M / 2012 / 25-hydroxyvitamin D concentrations in patients with optic neuritis as a clinically isolated syndrome and healthy controls / Int J Prev Med 3 (5) : 313

Jee D / 2016

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