Mercury Exposure in Association With Decrease of Liver Function in Adults: A Longitudinal Study

최종혁; 배상혁; 임형렬; 임지애; 이용한; 하미나; 권호장

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자료유형: 학술저널

저자정보: 최종혁 배상혁 임형렬 임지애 이용한 하미나 권호장

저널정보: 대한예방의학회 예방의학회지 예방의학회지 제50권 제6호

발행연도: 2017.1

수록면: 377 - 385 (9page)

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Objectives: Although mercury (Hg) exposure is known to be neurotoxic in humans, its effects on liver function have been less often reported. The aim of this study was to investigate whether total Hg exposure in Korean adults was associated with elevated serum levels of the liver enzymes aspartate aminotransferase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT). Methods: We repeatedly examined the levels of total Hg and liver enzymes in the blood of 508 adults during 2010-2011 and 2014-2015. Cross-sectional associations between levels of blood Hg and liver enzymes were analyzed using a generalized linear model, and nonlinear relationships were analyzed using a generalized additive mixed model. Generalized estimating equations were applied to examine longitudinal associations, considering the correlations of individuals measured repeatedly. Results: GGT increased by 11.0% (95% confidence interval [CI], 4.5 to 18.0%) in women and 8.1% (95% CI, -0.5 to 17.4%) in men per doubling of Hg levels, but AST and ALT were not significantly associated with Hg in either men or women. In women who drank more than 2 or 3 times per week, AST, ALT, and GGT levels increased by 10.6% (95% CI, 4.2 to 17.5%), 7.7% (95% CI, 1.1 to 14.7%), and 37.5% (95% CI,15.2 to 64.3%) per doubling of Hg levels, respectively, showing an interaction between blood Hg levels and drinking. Conclusions: Hg exposure was associated with an elevated serum concentration of GGT. Especially in women who were frequent drinkers, AST, ALT, and GGT showed a significant increase, with a significant synergistic effect of Hg and alcohol consumption.

#Mercury #Aspartate aminotransferases #Alanine transaminase #Gamma-glutamyltransferase #Interaction

참고문헌 (21)

참고문헌 신청

Awata H / 2017 / Biomarker levels of toxic metals among Asian populations in the United States: NHANES 2011-2012 / Environ Health Perspect 125 (3) : 306 ~ 313

Cave M / 2010 / Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004 / Environ Health Perspect 118 (12) : 1735

Fernandes Azevedo B / 2012 / Toxic effects of mercury on the cardiovascular and central nervous systems / J Biomed Biotechnol 2012 : 949048 ~

Futatsuka M / 1992 / An epidemiological study with risk analysis of liver diseases in the general population living in a methyl mercury polluted area / J Epidemiol Community

Genchi G / 2017 / Mercury exposure and heart diseases / Int J Environ Res Public Health 14 (1) : E74 ~

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