지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
The object of this study is to investigate the effects of intermittent cyclic stretching on the smooth muscle cells (SMCs) seeded onto aligned multi-layered fibrous scaffold. To make multi-layered fibrous scaffold, polyurethane (PU) and poly(ethylene oxide) (PEO) were electrospun alternatively, then were immersed into distilled water to extract PEO. Various types of scaffolds were fabricated depending on fiber directions, i.e., aligned or randomly oriented. The direction of stretching was either parallel or vertical to the fiber direction for the aligned scaffolds. The stretching was also applied to the randomly aligned scaffolds. The duration of stretching was 2 min with 15 min resting period. During the stretching, the maximum and minimum strain was adjusted to be 10 and 7%, respectively with the frequency of 1 Hz. The bioactivities of cells on the scaffolds were assessed by quantifying DNA, collagen, and glycosaminoglycan (GAG) levels. And the cell morphology was observed by staining F-actin. SMCs under parallel stretching to the fiber direction responded more positively than those in other conditions. From the results, we could explain the morphological effect of a substrate on cellular activities. In addition the synergistic effects of substrate and mechanical stimuli effects were confirmed.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행
Birukov KG / 1995 / Stretch affects phenotype and proliferation of vascular smooth muscle cells,” Mol Cell Biochem / Mol Cell Biochem 144 : 131 ~ 139
Birukov KG / 2003 / Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch / Am J Physiol Lung Cell Mol Physiol 285 : L785 ~ L797
Cha JM / 2006 / Time-dependent modulation of alignment and differentiation of smooth muscle cells seeded on a porous substrate undergoing cyclic mechanical strain / Artif Org
Chapman GB / 2000 / Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells / Am J Physiol Hear Circ Physiol 278 : H748 ~ H754
Birukov KG / 1995 / Stretch affects phenotype and proliferation of vascular smooth muscle cells,” Mol Cell Biochem / Mol Cell Biochem 144 : 131 ~ 139
Birukov KG / 2003 / Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch / Am J Physiol Lung Cell Mol Physiol 285 : L785 ~ L797
Cha JM / 2006 / Time-dependent modulation of alignment and differentiation of smooth muscle cells seeded on a porous substrate undergoing cyclic mechanical strain / Artif Org
Chapman GB / 2000 / Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells / Am J Physiol Hear Circ Physiol 278 : H748 ~ H754
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