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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background: Tendons play an important role in transferring stress between muscles and bones and in maintaining the stability of joints. Tendon tears are difficult to heal and are associated with high recurrence rates. So, the objective of this study was to develop a biodegradable scaffold for tendon-bone junction regeneration. Methods: Two types of polylactic acid (PLA) yarns, having fibers with round and four deep grooved cross-sections, were braided into tubular scaffolds and cultured with murine Transforming growth factor beta type II receptor (Tgfbr2)-expressing joint progenitor cells. The scaffolds were designed to mimic the mechanical, immuno-chemical and biological properties of natural mouse tendon-bone junctions. Three different tubular scaffolds measuring 2mm in diameter were braided on a Steeger 16-spindle braiding machine and biological and mechanical performance of the three scaffolds were evaluated. Results: The mechanical test results indicated that three different braided scaffold structures provided a wide range of mechanical properties that mimic the components of tendon bone junction and results of the biological tests confirmed cell viability, active cell attachment and proliferation throughout all three scaffolds. Conclusions: This study has identified that the three proposed types of braided scaffolds with some improvement in their structures have the potential to be used as scaffolds for the regeneration of a tendon bone tissue junction.
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참고문헌 (24)
참고문헌 신청
Smith L / 2012 / Tissue-engineering strategies for the tendon/ligament-to-bone insertion / Connect Tissue Res 53(2):95~105
Heard H / 2016 / Update for the evaluation and treatment of Achilles tendon injuries / Gavin J Orthop Res Ther 2016:23~26
Lu HH / 2010 / Tissue engineering strategies for the regeneration of orthopedic interfaces / Ann Biomed Eng 38(6):2142~2154
Spalazzi JP / 2008 / In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration / J Biomed Mat Res A 86(1):1~2
Yang PJ / 2009 / Engineering orthopedic tissue interfaces / Tissue Eng B Rev 15(2):127~141
Heard H / 2016 / Update for the evaluation and treatment of Achilles tendon injuries / Gavin J Orthop Res Ther 2016:23~26
Lu HH / 2010 / Tissue engineering strategies for the regeneration of orthopedic interfaces / Ann Biomed Eng 38(6):2142~2154
Spalazzi JP / 2008 / In vivo evaluation of a multiphased scaffold designed for orthopaedic interface tissue engineering and soft tissue-to-bone integration / J Biomed Mat Res A 86(1):1~2
Yang PJ / 2009 / Engineering orthopedic tissue interfaces / Tissue Eng B Rev 15(2):127~141
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