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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 628 - 634 (7page)
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초록· 키워드
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Objectives : the effect of different sterilization methods on the surface morphology of PPDO-hybrid-PLGA nanofiber scaffold and attachments of
PC12 cell were investigated.
Methods : Poly (p-dioxone)-hybrid-Poly (lactide-glycolide) (PPDO-hybrid-PLGA) nanofiber scaffold, fabricated in a tube form with 1.5 mm internal
diameter, 0.2 mm thickness and 5 mm length, was prepared using electrospinning method. To study the surface morphology using SEM, The study
group and control group in respective were; Control:Non-sterilized scaffold, Group I:scaffold sterilized with 70% Alcohol, Group II: scaffold sterilized
with Ethylene Oxide at 65 ℃ , and Group Ⅲ: scaffold sterilized with Ethylene Oxide at 37 ℃. To investigate viability of the PC12 cell on the
scaffold, The study group and control group in respective were; Control: sterilized with 70% Alcohol, Group I: sterilized with Ethylene Oxide at 65
℃, and Group II: sterilized with Ethylene Oxide at 37 ℃.
Results : 1. The surface morphology was slightly changed in Group I, II and GroupⅢ, compared with control.
2. The attachment of PC12 cells in Group I, II was not higher than in control
Discussion : The attachment of PC12 cell is not influenced by different sterilization methods.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Calis S / 2002 / Influence of irradiation sterilization on poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs / Farmaco 57 (1) : 55 ~ 62
Carrascosa C / 2003 / Effect of gammasterilization process on PLGA microspheres loaded with insulinlike growth factor-I (IGF-I) / J Biomater Appl 18 (2) : 95 ~ 108
Chia NK / 2008 / Controlled degradation of multilayered poly(lactide-co-glycolide) films using electron beam irradiation / J Biomed Mater Res A 84 (4) : 980 ~ 987
Friess W / 2006 / Sterilization of gentamicin containing collagen/ PLGA microparticle composites / Eur J Pharm Biopharm 63 (2) : 176 ~ 187
Gardener JF PM / 1991 / Introduction to sterilization, disinfection and infection control / NY:Churchill Livingston
Carrascosa C / 2003 / Effect of gammasterilization process on PLGA microspheres loaded with insulinlike growth factor-I (IGF-I) / J Biomater Appl 18 (2) : 95 ~ 108
Chia NK / 2008 / Controlled degradation of multilayered poly(lactide-co-glycolide) films using electron beam irradiation / J Biomed Mater Res A 84 (4) : 980 ~ 987
Friess W / 2006 / Sterilization of gentamicin containing collagen/ PLGA microparticle composites / Eur J Pharm Biopharm 63 (2) : 176 ~ 187
Gardener JF PM / 1991 / Introduction to sterilization, disinfection and infection control / NY:Churchill Livingston
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