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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 226 - 232 (7page)
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Background: Breast cancer is the most common type of cancer in females. Aberrant expression of microRNA-21 (miR-21) has previously been reported in breast cancer tissue. The aim of this study was to investigate expression levels of serum miR-21 in breast cancer patients and evaluate its prognostic value in Chinese females.
Methods: Real-time quantitative (RQ)-PCR was used to analyze miR-21 expression in archived serum, tumor tissue, and adjacent normal tissue from 549 participants (326 with breast cancer, 223 without breast cancer). We also analyzed associations between serum miR-21 expression and breast cancer subtypes and patient prognosis. Recurrence and survival were analyzed by using the multivariate Cox proportional hazards model.
Results: Expression of miR-21 was significantly higher in breast cancer tissues compared with normal adjacent breast tissues (P<0.001). The 2-ΔΔCt values for serum miR-21 in breast cancer patients versus healthy controls were 9.12±3.43 and 2.96±0.73, respectively. Multivariate Cox proportional hazards model suggested that serum miR-21 expression was an independent poor prognostic factor for both recurrence (hazard ratio [HR]= 2.942; 95% confidence interval [CI]=1.420-8.325; P=0.008) and disease-free survival (HR=2.732; 95% CI=1.038-7.273, P=0.003) in breast cancer.
Conclusions: Increased serum miR-21 expression level was correlated with poor prognosis of breast cancer patients, indicating that serum miR-21 may be a novel prognostic marker for recurrence and survival of breast cancer patients before resection.
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참고문헌 (26)
참고문헌 신청
Asaga S / 2011 / Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer / Clin Chem 57 : 84 ~ 91
Calin GA / 2004 / Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers / Proc Natl Acad Sci USA 101 : 2999 ~ 3004
Calin GA / 2007 / Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications / J Clin Invest 117 : 2059 ~ 2066
Chan M / 2013 / Identification of circulating microRNA signatures for breast cancer detection / Clin Cancer Res 19 : 4477 ~ 4487
Cortez MA / 2011 / MicroRNAs in body fluids--the mix of hormones and biomarkers / Nat Rev Clin Oncol 8 : 467 ~ 477
Calin GA / 2004 / Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers / Proc Natl Acad Sci USA 101 : 2999 ~ 3004
Calin GA / 2007 / Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications / J Clin Invest 117 : 2059 ~ 2066
Chan M / 2013 / Identification of circulating microRNA signatures for breast cancer detection / Clin Cancer Res 19 : 4477 ~ 4487
Cortez MA / 2011 / MicroRNAs in body fluids--the mix of hormones and biomarkers / Nat Rev Clin Oncol 8 : 467 ~ 477
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