지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 94 - 98 (5page)
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초록· 키워드
오류제보하기
Background: Periodic monitoring of antimicrobial resistance trends of clinically important anaerobic bacteria such as Bacteroides fragilis group organisms is required. We determined the antimicrobial susceptibilities of clinical isolates of B. fragilis group organisms recovered from 2009 to 2012 in a tertiary-care hospital in Korea.
Methods: A total of 180 nonduplicate clinical isolates of B. fragilis group organisms were collected in a tertiary care hospital. The species were identified by conventional methods: the ATB 32A rapid identification system (bioMérieux, France) and the Vitek MS matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (bioMérieux). Antimicrobial susceptibility was determined by the CLSI agar dilution method.
Results: Imipenem and meropenem resistance rates were 0-6% for B. fragilis group isolates. The rate of resistance to piperacillin-tazobactam was 2% for B. fragilis and 0% for other Bacteroides species, but 17% for B. thetaiotaomicron isolates. High resistance rates to piperacillin (72% and 69%), cefotetan (89% and 58%), and clindamycin (83% and 69%) were observed for B. thetaiotaomicron and other Bacteroides spp. The moxifloxacin resistance rate was 27% for other Bacteroides spp. The MIC50 and MIC90 of tigecycline were 2-4 μg/mL and 8-16 μg/mL, respectively. No isolates were resistant to chloramphenicol or metronidazole.
Conclusions: Imipenem, meropenem, chloramphenicol, and metronidazole remain active against B. fragilis group isolates. Moxifloxacin and tigecycline resistance rates are 2-27% and 8-15% for B. fragilis group isolates, respectively.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Betriu C / 2005 / Changing patterns of fluoroquinolone resistance among Bacteroides fragilis group organisms over a 6-year period (1997-2002) / Diagn Microbiol Infect Dis 53
Brazier JS / 1999 / Metronidazole resistance among clinical isolates belonging to the Bacteroides fragilis group: time to be concerned? / J Antimicrob Chemothery 44 : 580 ~
Brook I / 2013 / Antianaerobic antimicrobials: spectrum and susceptibility testing / Clin Microbiol Rev 26 : 526 ~ 546
CLSI / 2012 / Methods for Antimicrobial susceptibility testing of anaerobic bacteria; Approved standard, 8th ed. CLSI document M11-A8 / Clinical and Laboratory Standards Institute
European Committee on Antimicrobial Susceptibility Testing / / Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1
Brazier JS / 1999 / Metronidazole resistance among clinical isolates belonging to the Bacteroides fragilis group: time to be concerned? / J Antimicrob Chemothery 44 : 580 ~
Brook I / 2013 / Antianaerobic antimicrobials: spectrum and susceptibility testing / Clin Microbiol Rev 26 : 526 ~ 546
CLSI / 2012 / Methods for Antimicrobial susceptibility testing of anaerobic bacteria; Approved standard, 8th ed. CLSI document M11-A8 / Clinical and Laboratory Standards Institute
European Committee on Antimicrobial Susceptibility Testing / / Breakpoint tables for interpretation of MICs and zone diameters. Version 3.1
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