지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 479 - 486 (8page)
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초록· 키워드
오류제보하기
Background: Periodic monitoring of regional or institutional resistance trends of clinically important anaerobic bacteria is recommended, because the resistance of anaerobic pathogens to antimicrobial drugs and inappropriate therapy are associated with poor clinical outcomes. There has been no multicenter study of clinical anaerobic isolates in Korea. We aimed to determine the antimicrobial resistance patterns of clinically important anaerobes at multiple centers in Korea.
Methods: A total of 268 non-duplicated clinical isolates of anaerobic bacteria were collected from four large medical centers in Korea in 2012. Antimicrobial susceptibility was tested by the agar dilution method according to the CLSI guidelines. The following antimicrobials were tested: piperacillin, piperacillin-tazobactam, cefoxitin, cefotetan, imipenem, meropenem, clindamycin, moxifloxacin, chloramphenicol, metronidazole, and tigecycline.
Results: Organisms of the Bacteroides fragilis group were highly susceptible to piperacillin-tazobactam, imipenem, and meropenem, as their resistance rates to these three antimicrobials were lower than 6%. For B. fragilis group isolates and anaerobic gram-positive cocci, the resistance rates to moxifloxacin were 12-25% and 11-13%, respectively. Among B. fragilis group organisms, the resistance rates to tigecycline were 16-17%. Two isolates of Finegoldia magna were non-susceptible to chloramphenicol (minimum inhibitory concentrations of 16-32 mg/L). Resistance patterns were different among the different hospitals.
Conclusions: Piperacillin-tazobactam, cefoxitin, and carbapemems are highly active β-lactam agents against most of the anaerobes. The resistance rates to moxifloxacin and tigecycline are slightly higher than those in the previous study.
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참고문헌 (22)
참고문헌 신청
Brook I / 2013 / Antianaerobic antimicrobials: spectrum and susceptibility testing / Clin Microbiol Rev 26 : 526 ~ 546
Citron DM / 2007 / Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents / J Clin Microbiol 45 : 2819 ~ 2828
Citron DM / 2011 / Manual of clinical microbiology / ASM Press : 1204 ~ 1214
Clinical and Laboratory Standards Institute / 2012 / Methods for antimicrobial susceptibility testing of anaerobic bacteria; Approved standard, 8th ed. M11-A8 / Clinical and Laboratory
Goldstein EJ / 2011 / Clinical efficacy and correlation of clinical outcomes with in vitro susceptibility for anaerobic bacteria in patients with complicated intra-abdominal
Citron DM / 2007 / Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents / J Clin Microbiol 45 : 2819 ~ 2828
Citron DM / 2011 / Manual of clinical microbiology / ASM Press : 1204 ~ 1214
Clinical and Laboratory Standards Institute / 2012 / Methods for antimicrobial susceptibility testing of anaerobic bacteria; Approved standard, 8th ed. M11-A8 / Clinical and Laboratory
Goldstein EJ / 2011 / Clinical efficacy and correlation of clinical outcomes with in vitro susceptibility for anaerobic bacteria in patients with complicated intra-abdominal
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