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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제2호
- 발행연도
- 2018.1
- 수록면
- 153 - 160 (8page)
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초록· 키워드
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Objective: D-galactose has been commonly used in rodent models to induce accelerated effects of aging, including those on learning, memory, and muscular tone and coordination. This is normally seen on chronic administration of D-galactose. However, there is minimal suggestive evidence on the short-term effects of the same. The aim of the study was to study the acute and chronic effects of D-galactose on learning and memory in Wistar rats. Methods: Twenty four male Wistar rats were randomly assigned to the control, standard (rivastigmine), oral D-galactose (200 mg/kg/day) and subcutaneous D-galactose (200 mg/kg/day) for a total duration of 8 weeks. Effects on learning and memory were assessed at 2 weeks, 4 weeks and 8 weeks by Morris water maze model and passive avoidance testing. Results: Both oral and subcutaneous D-galactose showed positive effects on learning and memory on acute dosing, whereas this beneficial effect was lost during chronic dosing. Conclusion: Short-term administration of D-galactose showed positive effects, while long-term administration nullified these effects.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Chen CF / 2006 / Effects of D-galactose on the expression of hippocampal peripheral-type benzodiazepine receptor and spatial memory performances in rats / Psychoneuroendocrinology 31:805~811
Gropper SS / 2000 / Free galactose content of fresh fruits and strained fruit and vegetable baby foods: more foods to consider for the galactose-restricted diet / J Am Diet Assoc 100:573~575
Parameshwaran K / 2010 / D-galactose effectiveness in modeling aging and therapeutic antioxidant treatment in mice / Rejuvenation Res 13:729~735
Budni J / 2016 / Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats / Behav Brain Res 302:35~43
Salkovic-Petrisic M / 2014 / Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin / Neuropharmacology 77:68~80
Gropper SS / 2000 / Free galactose content of fresh fruits and strained fruit and vegetable baby foods: more foods to consider for the galactose-restricted diet / J Am Diet Assoc 100:573~575
Parameshwaran K / 2010 / D-galactose effectiveness in modeling aging and therapeutic antioxidant treatment in mice / Rejuvenation Res 13:729~735
Budni J / 2016 / Oral administration of d-galactose induces cognitive impairments and oxidative damage in rats / Behav Brain Res 302:35~43
Salkovic-Petrisic M / 2014 / Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin / Neuropharmacology 77:68~80
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