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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제38권 제3호
- 발행연도
- 2008.1
- 수록면
- 511 - 520 (10page)
이용수
초록· 키워드
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Purpose: Diabetes mellitus is a clinically and genetically heterogeneous group of metabolic disorders manifested by abnormally high levels of glucose in the blood. Mounting evidence demonstrates that diabetes is a risk factor for gingivitis and periodontitis. The circulating mononuclear phagocytes in diabetic patients with hyperglycemia are chronically exposed to high level of serum glucose. Thus, this study attempted to determine the effect of pre-exposure of monocytes and macrophages to high concentration of glucose on lipopolysaccharide (LPS)-induced production of pro-inflammatory mediators.
Material and Methods: For this purpose, cells were cultured in medium containing normal (5 mM) or high glucose (25 mM) for 4-5 weeks before treatment for 24 h with LPS. LPS was highly purified from Porphyromonas gingivalis or Prevotella intermedia by phenol extraction.
Result: Results showed that prolonged pre-exposure of cells to high glucose markedly increased LPS-stimulated NO secretion when compared to normal glucose. In addition to NO, high glucose also augmented LPS-stimulated IL-6, IL-8, and TNF-α secretion after cells were exposed to high glucose for 4 weeks.
Conclusion: The present study demonstrates that pre-exposure of mononuclear phagocytes with high glucose augments LPS-stimulated production of pro-inflammatory mediators. These findings may explain why periodontal tissue destruction in diabetic patients is more severe than that in non-diabetic individuals. (J Korean Acad Periodontol 2008;38:511-520)
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참고문헌 (23)
참고문헌 신청
Chung CP / 1983 / Bacterial IgG and IgM antibody titers in acute necrotizing ulcerative gingivitis / J Periodontol 54 : 557 ~ 562
Ficara A / 1975 / A comparison of the glucose and protein content of gingival fluid from diabetics and nondiabetics / J Periodontal Res 10 : 171 ~ 175
Geller DA / 1993 / Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes / Proc Natl Acad Sci USA 90 : 522 ~ 52
Hara K / 1969 / Carbohydrate components of the gingival exudate / J Periodontal Res 4 : 202 ~ 207
Hirose M / 2001 / Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue / J Periodontol 72 : 590 ~ 597
Ficara A / 1975 / A comparison of the glucose and protein content of gingival fluid from diabetics and nondiabetics / J Periodontal Res 10 : 171 ~ 175
Geller DA / 1993 / Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes / Proc Natl Acad Sci USA 90 : 522 ~ 52
Hara K / 1969 / Carbohydrate components of the gingival exudate / J Periodontal Res 4 : 202 ~ 207
Hirose M / 2001 / Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue / J Periodontol 72 : 590 ~ 597
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