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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 409 - 420 (12page)
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초록· 키워드
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Objectives : The purpose of this study was to identify the anti-tumor effects of realgar on various cancer cells through molecular biologic and cellular biologic methods.Materials & Methods : We used 5 kinds of cancer cell lines:stomach cancer cells (AGS), glioma cells (T98G, A172, SNU-489) and prostate cancer cells (LNCaP). We injected the boiled extract of realgar, 50㎍/ml and 100㎍/ml to culture media (㎖) for 24 hours. We examined the morphological changes under an inverted microscope and a fluorescence microscope. We measured the suppressive effect on viability of 5 kinds of cancer cells via XTT assay. We examined the effect on the revelation of PARP cleavage, Bcl-2 protein and Bax protein by western blot analysis.Results : The extract of realgar caused markedly morphological changes on AGS, T98G, SNU-489, and LNCaP. All of them showed withdrawn and floating appearance. The suppressive effect on viability of AGS, T98G, A172, SNU-489, and LNCaP showed that each test group had more suppressive effect on viability of AGS, T98G, A172, SNU-489, and LNCaP than the control group, which was statistically significantly (p<0.01). The extract of realgar did not induce PARP cleavage in AGS, T98G, A172, SNU-489, or LNCaP.In the revelation of protein related to apoptosis, the protein levels of Bcl-2 decreased and the protein levels of Bax increased in AGS, T98G, SNU-489, and LNCaP treated with realgar. The protein levels of Bcl-2 decreased and the protein levels of Bax did not change in A172 treated with realgar.Conclusions : This experiment showed that realgar has anti-tumor effect on stomach cancer cells (AGS), glioma cells (T98G, SNU-489), and prostate cancer cells (LNCaP)
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참고문헌 (35)
참고문헌 신청
/ / 2005년 사망원인별 사망자수 및 사망률
/ 1990 / 암의 최신지견 : 307 ~ 19
/ 1991 / An improved colormetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT : 257 ~ 65
/ 1993 / 抗癌劑 副作用에 대한 韓方療法 : 33 ~ 51
/ 1994 / Cleavage of poly polymerase by a proteinase with properties like ICE : 346 ~ 7
/ 1990 / 암의 최신지견 : 307 ~ 19
/ 1991 / An improved colormetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT : 257 ~ 65
/ 1993 / 抗癌劑 副作用에 대한 韓方療法 : 33 ~ 51
/ 1994 / Cleavage of poly polymerase by a proteinase with properties like ICE : 346 ~ 7
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