지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 115 - 126 (12page)
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초록· 키워드
오류제보하기
Background and Objectives：Deafness is the most comon sensory deficit and hereditary defect in human populations. The present study investigated the causative gene in circling mice using the complementation test. In addition, the phenotypes and histopathologic findings in circler mice, spinner mice, and compound heterozygote mice were analyzed to elucidate the mechanism of causative gene in inner ear deafness. Materials and Method：In order to analyze inner ear pathology in time sequence for 10, 18, 21, 35, and 90 days old. The organs of Corti and spiral ganglion neurons in the basal and middle turns were included for quantification. For the preparation of genomic DNA, tail tissues were used. Results：The hair cells in the organ of Corti dege-nerated in a time-dependent manner. In the basal and middle turns, the volume ratio of spiral ganglion neurons significantly decreased as the mutant aged. RT-PCR analysis indicated that transmembrane iner ear (Tmie) was absent in the case of circler mice, similar to spinner mouse of which is defective Tmie gene. Therefore the variations may be a result from strain-specific Tmie gene itself (allelic heterogeneity). Conclusion：The cir mutant is a suitable mouse model for neuroepithelial defects. PCR and RT-PCR analyses suggest that the Tmie transcript is absent in circler mice. This model represents another candidate for human genetic hearing loss.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1962 / The spinner mouse 53 : 133 ~ 136
/ 1986 / Ion-induced DNA structurechange in nucleosomes 25 : 5070 ~ 5082
/ 1991 / Genetic epidermiology of hearing impairment 630 : 16 ~ 31
/ 1992 / Ultrastructuralfindings in the inner ear of Jackson shaker mice 112 : 622 ~ 627
/ 1993 / Genetic epidemiological studies of early-onset deafnessin the U 46 : 486 ~ 491
/ 1986 / Ion-induced DNA structurechange in nucleosomes 25 : 5070 ~ 5082
/ 1991 / Genetic epidermiology of hearing impairment 630 : 16 ~ 31
/ 1992 / Ultrastructuralfindings in the inner ear of Jackson shaker mice 112 : 622 ~ 627
/ 1993 / Genetic epidemiological studies of early-onset deafnessin the U 46 : 486 ~ 491
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The different rescue levels in the circling mouse with Transmembrane inner ear (tmie) gene are dependent on the expression patterns of transgene in the cochlea
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2008 .05
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The Different Rescue Levels in the Circling Mouse with Transmembrane Inner Ear (Tmie) Gene are Dependent on the Expression Patterns of Transgene in the Cochlea
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The different rescue levels in the circling mouse with Transmembrane inner ear (tmie) gene are dependent on the expression patterns of transgene in the cochlea
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Subcellular localization of the transmembrane inner ear (Tmie) protein in a stable Tmie-expressing cell line
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2011 .12
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Genetic Studies on the Circling Mice, Identifying the Mutant Gene
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2004 .06
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Tmie is Necessary Protein for Mechanotransduction of Hair Cells
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